About: D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis
Creator	Li, Huan Wang, Qiang Ren, Hongwei Zhang, Xiaoli Wu, Qingming Long, Hui Xiang, Xiaochen Fu, Xiaozhi Liu, Wanxin Nie, Lan
Source	Medline; PMC
abstract	OBJECTIVE: To investigate the value of coagulation indicators D-dimer (DD), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (Fg) in predicting the severity and prognosis of COVID-19. METHODS: A total of 115 patients with confirmed COVID-19, who were admitted to Tianyou Hospital of Wuhan University of Science and Technology between January 18, 2020, and March 5, 2020, were included. The dynamic changes of DD, PT, APTT, and Fg were tested, and the correlation with CT imaging, clinical classifications, and prognosis was studied. RESULTS: Coagulation disorder occurred at the early stage of COVID-19 infection, with 50 (43.5%) patients having DD increased and 74 (64.3%) patients having Fg increased. The levels of DD and Fg were correlated with clinical classification. Among 23 patients who deceased, 18 had DD increased at the first lab test, 22 had DD increased at the second and third lab tests, and 18 had prolonged PT at the third test. The results from ROC analyses for mortality risk showed that the AUCs of DD were 0.742, 0.818, and 0.851 in three times of test, respectively; PT was 0.643, 0.824, and 0.937. In addition, with the progression of the disease, the change of CT imaging was closely related to the increase of the DD value (P < 0.01). CONCLUSIONS: Coagulation dysfunction is more likely to occur in severe and critically ill patients. DD and PT could be used as the significant indicators in predicting the mortality of COVID-19.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.1155/2020/6159720
bibo:pmid	32596339
has license	cc-by
sha1sum (hex)	9ef3cf228c3c6e5ca6b2cd9054807ff9d68d2076
schema:url	https://doi.org/10.1155/2020/6159720
resource representing a document's title	D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis
has PubMed Central identifier	PMC7301188
has PubMed identifier	32596339
schema:publication	Biomed Res Int
resource representing a document's body	covid:9ef3cf228c3c6e5ca6b2cd9054807ff9d68d2076#body_text
is schema:about of	named entity 'TEST' named entity 'COAGULATION' named entity 'Coagulation disorder' named entity 'CT imaging' named entity 'COVID' named entity 'immune response' named entity 'coagulation' named entity 'coagulating' named entity 'COVID' named entity 'coagulating' named entity 'APTT' named entity 'prognosis' named entity 'multiple organ dysfunction syndrome' named entity 'COVID' named entity 'COVID-19' named entity 'hospital discharge' named entity 'CT imaging' named entity 'COVID-19' named entity 'COVID' named entity 'DIC' named entity 'Fg1' named entity 'angiotensin-converting enzyme 2' named entity 'disseminated intravascular coagulation' named entity 'coagulation' named entity 'virus' named entity 'hospital discharge' named entity 'COVID' named entity 'fibrinolytic' named entity 'respiratory droplets' named entity 'ICU' named entity 'CT imaging' named entity 'Fg1' named entity 'liver' named entity 'standard deviations' named entity 'COVID-19' named entity 'hospital discharge' named entity 'SARS-CoV-2' named entity 'fibrinolytic' named entity 'COVID' named entity 'coagulation' named entity 'ordered variables' named entity 'respiratory tract' named entity 'thrombosis' named entity '1.10' named entity 'APTT' named entity 'multiple organ failure' named entity 'prognosis' named entity 'PAMP' named entity 'ROC curve' named entity 'dyspnea' named entity 'fibrinolysis' named entity 'Prognosis' named entity 'coronavirus' named entity 'lesion' named entity 'DIC' named entity 'thrombotic complications' named entity 'fibrinolytic' named entity 'morbidity' named entity 'ROC curve' named entity 'control group' named entity 'RT-PCR' named entity 'APTT' named entity 'critically ill patients' named entity 'cytokine storm' named entity 'respiratory failure' named entity 'pulmonary embolism' named entity 'DIC' named entity 'Wuhan' named entity 'fibrinolytic' named entity 'coagulation' named entity 'autopsy' named entity 'COVID'

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