About: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

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About: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
Creator	Klingström, Jonas Albert, Jan Price, David Ljunggren, Hans-Gustaf Allander, Tobias Gredmark-Russ, Sara Nielsen, Morten Sandberg, Johan Aleman, Soo Bogdanovic, Gordana Rooyackers, Olav Sönnerborg, Anders Martín, San Björkström, Niklas Buggert, Marcus Emgård, Johanna Eriksson, Lars Folkesson, Elin Gorin, Jean-Baptiste Kamal, Habiba Kammann, Tobias Llewellyn-Lacey, Sian Muschiol, Sandra Olsson, Annika Parrot, Tiphaine Perez-Potti, André Rivera-Ballesteros, Olga Sekine, Takuya Strålin, Kristoffer Wullimann, David Group, Covid-19 Karolinska, ;
source	BioRxiv
abstract	SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in a large cohort of unexposed individuals as well as exposed family members and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative family members and individuals with a history of asymptomatic or mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses akin to those observed in the context of successful vaccines, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1101/2020.06.29.174888
has license	biorxiv
sha1sum (hex)	9fa90be4a0871bce6c7e617b7079c12c5542a0f8
schema:url	https://doi.org/10.1101/2020.06.29.174888
resource representing a document's title	Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
schema:publication	bioRxiv
resource representing a document's body	covid:9fa90be4a0871bce6c7e617b7079c12c5542a0f8#body_text
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