About: Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

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About: Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex
Creator	Zheng, Bo-Jian Jin, Dong-Yan Yuen, Kwok-Yung Kok, Kin-Hang Siu, Kam-Leung Poon, Vincent Ng, Ming-Him
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) coronavirus is highly pathogenic in humans and evades innate immunity at multiple levels. It has evolved various strategies to counteract the production and action of type I interferons, which mobilize the front-line defense against viral infection. In this study we demonstrate that SARS coronavirus M protein inhibits gene transcription of type I interferons. M protein potently antagonizes the activation of interferon-stimulated response element-dependent transcription by double-stranded RNA, RIG-I, MDA5, TBK1, IKKϵ, and virus-induced signaling adaptor (VISA) but has no influence on the transcriptional activity of this element when IRF3 or IRF7 is overexpressed. M protein physically associates with RIG-I, TBK1, IKKϵ, and TRAF3 and likely sequesters some of them in membrane-associated cytoplasmic compartments. Consequently, the expression of M protein prevents the formation of TRAF3·TANK·TBK1/IKKϵ complex and thereby inhibits TBK1/IKKϵ-dependent activation of IRF3/IRF7 transcription factors. Taken together, our findings reveal a new mechanism by which SARS coronavirus circumvents the production of type I interferons.
has issue date	2009-04-20(xsd:dateTime)
bibo:doi	10.1074/jbc.m109.008227
bibo:pmid	19380580
has license	bronze-oa
schema:url	https://doi.org/10.1074/jbc.m109.008227
resource representing a document's title	Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex
has PubMed Central identifier	PMC2713514
has PubMed identifier	19380580
schema:publication	Journal of Biological Chemistry
resource representing a document's body	covid:PMC2713514#body_text
is schema:about of	named entity 'FORMATION' named entity 'PROTEIN ' named entity 'M PROTEIN' named entity 'COMPLEX' named entity 'PRODUCTION' named entity 'IMPEDING' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'TYPE I' named entity 'TANK' named entity 'Severe Acute Respiratory Syndrome Coronavirus' named entity 'TBK1' named entity 'IRF3' named entity 'SARS coronavirus' named entity 'M protein' named entity 'protein' named entity 'cytoplasmic' named entity 'VISA' named entity 'TRAF3' named entity 'protein expression' named entity 'TRAF6' named entity 'RNA polymerase II' named entity 'protein' named entity 'protein' named entity 'cellular signaling' named entity 'TRAF3' named entity 'HEK293' named entity 'GM130' named entity 'protein' named entity 'SARS coronavirus' named entity 'IκBα' named entity 'TBK1' named entity 'protein' named entity 'multiplicity of infection' named entity 'Ebola virus' named entity 'gene transcription' named entity 'phosphorylation' named entity 'protein' named entity 'SARS' named entity 'TBK1' named entity 'dsRNA' named entity 'type I interferons' named entity 'Japan' named entity 'interferon β' named entity 'Cardif' named entity 'protein' named entity 'IRF3' named entity 'protein' named entity 'SARS coronavirus' named entity 'IRF7' named entity 'long terminal repeats' named entity 'β-mercaptoethanol' named entity 'interferon β' named entity 'luciferase' named entity 'SARS coronavirus' named entity 'SARS coronavirus' named entity 'cytoplasm' named entity 'interferon' named entity 'NLRX1' named entity 'TBK1' named entity 'SARS coronavirus' named entity 'protein' named entity 'SARS coronavirus' named entity 'luciferase' named entity 'protein' named entity 'kinase' named entity 'papain' named entity 'TRAF3' named entity 'M protein' named entity 'pathogenesis' named entity 'protein' named entity 'IRF7' named entity 'protein' named entity 'TRAF3' named entity 'Western blotting' named entity 'protein' named entity 'TBK1'

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