About: A Novel Strategy for Bitter Taste Masking of Gankeshuangqing Dispersible Tablets Based on Particle Coating Technology

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About: A Novel Strategy for Bitter Taste Masking of Gankeshuangqing Dispersible Tablets Based on Particle Coating Technology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Novel Strategy for Bitter Taste Masking of Gankeshuangqing Dispersible Tablets Based on Particle Coating Technology
Creator	Yang, Ming Han, Xue Han, Li Jiang, Hong Zhang, Fang Fu, Chao-Mei Lan, Yang Lin, Jun-Zhi Xiong, Xi Zhang, Ding-Kun
Source	PMC
abstract	BACKGROUND: Currently, acute upper respiratory tract infections (AURTIs) are increasingly becoming a significant health burden. Gankeshuangqing dispersible tablets (GKSQDT) which have a good effect on treating AURTIs. GKSQDT is composed of baicalin and andrographolide. However, its severe bitterness limits application of patients. Due to the addition of plentiful accessories, common masking methods are unsuitable for GKSQDT. It is thus necessary to develop a new masking method. MATERIALS AND METHODS: The Previous study showed that baicalin was less bitter than andrographolide. Thus, particle coating technology was adapted to prepare composite particles that baicalin coated on the surface of andrographolide to decrease bitterness. Initially, particle size of baicalin and coating time of composite was investigated to prepare composite. Then, scanning electron microscopy, wettability, and infrared (IR) spectrogram were used to characterize the microstructure of composite. Furthermore, electronic tongue test, animal preference experiment, and human sensory test were applied to evaluate the masking effect. RESULTS: To produce composite, baicalin should be ground in vibromill for 6 min. Then, andrographolide fine powder was added to grind together for 6 min. Contact angle of composite was smaller than mixture, and more similar to baicalin. Other physical characterization including microstructure, wettability, and IR also suggested that andrographolide was successfully coated by baicalin superfine. Furthermore, taste-masking test indicated taste-masked tablets was less bitter than original tablets. CONCLUSION: The study indicated that particle coating technology can be used for taste masking of GKSQDT without adding other substance. Moreover, it provides a new strategy of taste masking for national medicine. SUMMARY: A new strategy to mask bitterness without adding any other substance based on coating technology was provided. The masking effect was confirmed by electronic tongue test, animal preference experiment and human sensory test. Abbreviations used: AURTIs: Acute Upper Respiratory Tract Infections; GSQDT: Gankeshuangqing Dispersible Tablets; IR: Infrared Spectrogram; LHPC: Low-substituted Hydroxypropyl Cellulose; CAs: Contact Angles; FTIR: Fourier Transform Infrared Spectra.
has issue date	2017-07-19(xsd:dateTime)
bibo:doi	10.4103/pm.pm_240_16
bibo:pmid	28839363
has license	cc-by-nc-sa
schema:url	https://doi.org/10.4103/pm.pm_240_16
resource representing a document's title	A Novel Strategy for Bitter Taste Masking of Gankeshuangqing Dispersible Tablets Based on Particle Coating Technology
has PubMed Central identifier	PMC5551356
has PubMed identifier	28839363
schema:publication	Pharmacogn Mag
resource representing a document's body	covid:PMC5551356#body_text
is schema:about of	named entity 'BASED' named entity 'Tablets' named entity 'PARTICLE' named entity 'TABLETS' named entity 'STRATEGY' named entity 'MASKING' named entity 'BITTER TASTE' named entity 'TECHNOLOGY' named entity 'NOVEL' named entity 'COATING' named entity 'Chemical Reagent' named entity 'andrographolide' named entity 'baicalin' named entity 'baicalin' named entity 'standard conditions' named entity 'France' named entity 'sensory evaluation' named entity 'IR spectra' named entity 'Baicalin' named entity 'adenosine monophosphate' named entity 'andrographolide' named entity 'solubility' named entity 'upper respiratory tract infections' named entity 'aspartame' named entity 'natural antibiotics' named entity 'materials science' named entity 'Euclidean distance' named entity 'laboratory conditions' named entity 'coughing' named entity 'drug release' named entity 'andrographolide' named entity 'pharmaceutical industry' named entity 'baicalin' named entity 'andrographolide' named entity 'baicalin' named entity 'sputum' named entity 'FT-IR' named entity 'China' named entity 'plastic' named entity 'Millipore' named entity 'baicalin' named entity 'andrographolide' named entity 'andrographolide' named entity 'modified release' named entity 'andrographolide' named entity 'adverse effects' named entity 'wettability' named entity 'Toulouse' named entity 'FTIR' named entity 'elderly people' named entity 'ion' named entity 'electronic tongue' named entity 'baicalin' named entity 'Euclidean distance' named entity 'ethanol' named entity 'bitter taste' named entity 'China' named entity 'andrographolide' named entity 'bitter taste receptors' named entity 'baicalin' named entity 'distilled water' named entity 'spectrogram' named entity 'baicalin' named entity 'viral infection' named entity 'andrographolide' named entity 'bitter taste' named entity 'sensory evaluation' named entity 'National Natural Science Foundation' named entity 'distilled water' named entity 'baicalin' named entity 'distilled water' named entity 'andrographolide' named entity 'FTIR'

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