About: Genome sequencing and analysis of a novel recombinant porcine epidemic diarrhea virus strain from Henan, China

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About: Genome sequencing and analysis of a novel recombinant porcine epidemic diarrhea virus strain from Henan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genome sequencing and analysis of a novel recombinant porcine epidemic diarrhea virus strain from Henan, China
Creator	Zhou, Enmin Zhang, Gaiping Guo, Junqing Qiao, Songlin Li, Renfeng Xie, Sha Yang, Yanyan
topic	covid:PMC7089116#this
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) has caused devastating impact on pig-rearing industry in China and current vaccine is not effective against the circulating PEDV variants. In the present study, the full-length genome sequence from a PEDV isolate (CH/HNQX-3/14) was determined. The complete genome sequence analysis showed that the CH/HNQX-3/14 possessed unique deletion regions in the S and ORF3 genes. It was identified as a recombinant strain using phylogenetic analysis and recombination detection program. Further analyses of the full-length sequence suggest that CH/HNQX-3/14 is a natural recombinant between the attenuated vaccine strains (CV777 and DR13) and circulating wild-type strain (CH/ZMDZY/11). The recombination occurred not only in structural protein-coding region (S1 and N genes) but also in non-structural protein-coding region (replicases 1a and ORF3 genes). These results provided new evidence that PEDV strains circulating in China underwent recombination between vaccine and field strains, suggesting that recombination contributes to the genetic diversity of PEDV. Our findings provide valuable information on PEDV evolution and underscore the need for ongoing surveillance of this economically important swine disease.
has issue date	2016-01-07(xsd:dateTime)
bibo:doi	10.1007/s11262-015-1254-1
bibo:pmid	26743534
has license	no-cc
schema:url	https://doi.org/10.1007/s11262-015-1254-1
resource representing a document's title	Genome sequencing and analysis of a novel recombinant porcine epidemic diarrhea virus strain from Henan, China
has PubMed Central identifier	PMC7089116
has PubMed identifier	26743534
schema:publication	Virus Genes
resource representing a document's body	covid:PMC7089116#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/PMC7089116
is schema:about of	named entity 'STRAIN' named entity 'GENOME SEQUENCING' named entity 'CHINA' named entity 'NOVEL' named entity 'HENAN' named entity 'ANALYSIS' named entity 'RECOMBINANT' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'recombinant' named entity 'nucleotide' named entity 'porcine' named entity 'virulent' named entity 'protein' named entity 'reverse transcription' named entity 'vaccine strain' named entity 'genomes' named entity 'PEDV' named entity 'recombination events' named entity 'cell-mediated immunity' named entity 'PEDV' named entity 'Anhui' named entity 'immunogenicity' named entity 'sequenced' named entity 'vaccines' named entity 'PEDV' named entity 'critical role' named entity 'China' named entity 'recombinant' named entity 'PEDV' named entity 'reagent' named entity 'Henan' named entity 'protein-coding sequences' named entity 'United States' named entity 'PEDV' named entity 'genome sequence' named entity 'replicases' named entity 'GenBank' named entity 'gene' named entity 'China' named entity 'recombinants' named entity 'recombination events' named entity 'vaccine' named entity 'England' named entity 'PEDV' named entity 'PEDV' named entity 'genetic variation' named entity 'vaccines' named entity 'United States' named entity 'vaccination' named entity 'China' named entity 'open reading frames' named entity 'PEDV' named entity 'replicase' named entity 'evolutionary process' named entity 'genome' named entity 'genome sequences' named entity 'amplicon' named entity 'evolution' named entity 'virus' named entity 'genome' named entity '0.01' named entity 'recombinant' named entity 'recombination' named entity 'swine' named entity 'nucleotide' named entity 'PEDV' named entity 'epitope' named entity 'genome sequencing' named entity 'genome' named entity 'phylogenetic tree' named entity 'genome sequence' named entity 'watery diarrhea' named entity 'genomes' named entity 'PEDV'

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