About: Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies
Creator	Abman, Steven Barker, Alex Browne, Lorna Buckner, J. DiMaria, Michael Fenster, Brett Fonseca, Brian Hunter, Kendall Ivy, D. Kheyfets, Vitaly Kollengode, Madhukar Mitchell, Max Morgan, Gareth Naresh, Nivedita Schäfer, Michal Shah, Anar Stenmark, Kurt Truong, Uyen Wilson, Neil
source	PMC
abstract	Despite different developmental and pathological processes affecting lung vascular remodeling in both patient populations, differences in 4D MRI findings between children and adults with PAH have not been studied. The purpose of this study was to compare flow hemodynamic state, including flow-mediated shear forces, between pediatric and adult patients with PAH matched by severity of pulmonary vascular resistance index (PVRi). Adults (n = 10) and children (n = 10) with PAH matched by pulmonary vascular resistance index (PVRi) and healthy adult (n = 10) and pediatric (n = 10) subjects underwent comprehensive 4D-flow MRI to assess peak systolic wall shear stress (WSS(max)) measured in the main (MPA), right (RPA), and left pulmonary arteries (LPA), viscous energy loss (E(L)) along the MPA-RPA and MPA-LPA tract, and qualitative analysis of secondary flow hemodynamics. WSS(max) was decreased in all pulmonary vessels in children with PAH when compared with the same age group (all P < 0.05). Similarly, WSS(max) was decreased in all pulmonary vessels in adult PAH patients when compared with healthy adult subjects (all P < 0.01). Average E(L) was increased in adult patients with PAH when compared with the same age group along both MPA-RPA (P = 0.020) and MPA-LPA (P = 0.025) tracts. There were no differences in E(L) indices between adults and pediatric patients. Children and adult patients with PAH have decreased shear hemodynamic forces. However, pathological flow hemodynamic formations appear to be more consistent in adult patients, whereas flow hemodynamic abnormalities appear to be more variable in children with PAH for comparable severity of PVRi. NEW & NOTEWORTHY Both children and adult patients with PAH have decreased shear hemodynamic forces inside the pulmonary arteries associated with the degree of vessel dilation and stiffness. These differences also exist between healthy normotensive children and adults. However, pathological flow hemodynamic formations appear to more uniform in adult patients, whereas in children with PAH flow, hemodynamic abnormalities appear to be more variable. Pathological flow formations appear not to have a major effect on viscous energy loss associated with the flow conduction through proximal pulmonary arteries.
has issue date	2019-05-01(xsd:dateTime)
bibo:doi	10.1152/ajpheart.00802.2018
bibo:pmid	30822118
has license	no-cc
schema:url	https://doi.org/10.1152/ajpheart.00802.2018
resource representing a document's title	Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies
has PubMed Central identifier	PMC7327229
has PubMed identifier	30822118
schema:publication	Am J Physiol Heart Circ Physiol
resource representing a document's body	covid:PMC7327229#body_text
is schema:about of	named entity 'CMR' named entity 'hemodynamics' named entity 'CMR' named entity 'arterial flow' named entity 'hemodynamic' named entity 'Vmax' named entity 'end-diastolic volume' named entity 'shear forces' named entity 'phase contrast imaging' named entity 'systolic' named entity 'general anesthesia' named entity 'central line' named entity 'pulmonary arteries' named entity 'non-normally distributed' named entity 'TAPSE' named entity 'LPA' named entity 'MRI' named entity 'viscous stress tensor' named entity 'lupus erythematosus' named entity 'MPA' named entity 'MRI' named entity 'hemodynamics' named entity 'pulmonary circulation' named entity 'proximal' named entity 'PAH' named entity 'vessel wall' named entity 'stiffness' named entity 'incompressible fluid' named entity 'correlation' named entity 'proximal' named entity 'PAH' named entity 'pulmonary arteries' named entity 'PAH' named entity 'flow rate' named entity 'RPA' named entity 'time period' named entity 'PAH' named entity 'end-diastolic volume' named entity 'shear forces' named entity 'MRI' named entity 'Cardiovascular Imaging' named entity 'MPA' named entity 'proximal' named entity 'MRI' named entity 'smooth muscle cell' named entity 'echo time' named entity 'PAH' named entity 'PAH' named entity 'pulmonary arteries' named entity 'body surface area' named entity 'LPA' named entity 'MRI' named entity 'hemodynamic' named entity 'pediatric' named entity 'pediatric' named entity 'vasculature' named entity 'pulmonary arteries' named entity 'pulmonary artery' named entity 'blood flow' named entity 'diffusion' named entity 'pediatric' named entity 'hemodynamic' named entity 'PVR' named entity 'pulmonary arteries'

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