About: Poor positive predictive value of influenza‐like illness criteria in adult transplant patients: a case for multiplex respiratory virus PCR testing

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About: Poor positive predictive value of influenza‐like illness criteria in adult transplant patients: a case for multiplex respiratory virus PCR testing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Poor positive predictive value of influenza‐like illness criteria in adult transplant patients: a case for multiplex respiratory virus PCR testing
Creator	Singh, Kamaljit Hodowanec, Aimee Ac, Hodowanec Claus, Jonathan Ja, Claus Poor, Singh
Source	Medline; PMC
abstract	BACKGROUND: Respiratory viral infections (RVIs) are a significant cause of morbidity and mortality among transplant patients. The CDC's influenza‐like illness (ILI) criteria (fever ≥100°F with cough and/or sore throat) are a screening tool for influenza with unknown applicability to the transplant population. METHODS: We reviewed all respiratory virus PCR tests performed on adult patients with a history of solid organ (SOT) or stem cell transplantation (HSCT) during the 2012–2013 influenza season. The positive (PPV) and negative predictive values (NPV) of ILI criteria were calculated. RESULTS: Of 126 transplant patients (66 HSCT, 60 SOT), 54 (42.8%) tested positive for an RVI by PCR: 24 influenza and 30 non‐influenza. Of 30 patients who met ILI criteria, 12 (40%) were positive for influenza. The PPV and NPV of ILI for influenza were 50% and 82.4%, respectively. Mortality was low (3.7%), but morbidity was high (14.8% required ICU stay) among transplant patients diagnosed with RVI. CONCLUSIONS: Influenza and non‐influenza RVIs are associated with significant morbidity among transplant patients. CDC ILI criteria correlate poorly with PCR‐positive cases of influenza in transplant patients, but may be useful in excluding the diagnosis. Routine RVI PCR testing is recommended for better diagnosis and improved antiviral use in transplant patients with suspected RVI.
has issue date	2015-09-03(xsd:dateTime)
bibo:doi	10.1111/ctr.12600
bibo:pmid	26338182
has license	no-cc
sha1sum (hex)	a048f31002dc5d2c5e690f8afa5ef076c6e05a2d
schema:url	https://doi.org/10.1111/ctr.12600
resource representing a document's title	Poor positive predictive value of influenza‐like illness criteria in adult transplant patients: a case for multiplex respiratory virus PCR testing
has PubMed Central identifier	PMC7162202
has PubMed identifier	26338182
schema:publication	Clin Transplant
resource representing a document's body	covid:a048f31002dc5d2c5e690f8afa5ef076c6e05a2d#body_text
is schema:about of	named entity 'case' named entity 'solid' named entity 'adult' named entity 'influenza' named entity 'CALCULATED' named entity 'TESTING' named entity 'POPULATION' covid:arg/a048f31002dc5d2c5e690f8afa5ef076c6e05a2d named entity 'fever' named entity 'respiratory' named entity 'morbidity' named entity 'influenza-like illness' named entity 'stem cell' named entity 'influenza-like illness' named entity 'influenza' named entity 'tested' named entity 'virus' named entity 'NPV' named entity 'screening tool' named entity 'influenza' named entity 'tested positive' named entity 'influenza' named entity 'morbidity' named entity 'influenza-like illness' named entity 'PCR tests' named entity 'virus' named entity 'PCR testing' named entity 'influenza' named entity 'negative predictive values' named entity 'ILI' named entity 'influenza' named entity 'influenza' named entity 'immunogenicity' named entity 'good match' named entity 'NPV' named entity 'CDC' named entity 'virus' named entity 'outpatient setting' named entity 'parainfluenza' named entity 'NPV' named entity 'ILI' named entity 'specificity and sensitivity' named entity 'Streptococcus pneumoniae' named entity 'influenza vaccines' named entity 'sore throat' named entity 'influenza' named entity 'oseltamivir' named entity 'pathogens' named entity 'ILI' named entity 'sore throat' named entity 'respiratory infections' named entity 'multiplex PCR' named entity 'Rush University Medical Center' named entity 'human metapneumovirus' named entity 'allogeneic' named entity 'PCR' named entity 'virus' named entity 'rhinovirus' named entity 'influenza' named entity 'cytomegalovirus' named entity 'multiplex PCR' named entity 'fever' named entity 'cough' named entity 'ILI' named entity 'viral pathogens' named entity 'influenza' named entity 'transplant recipients' named entity 'bacterial pneumonia' named entity 'influenza' named entity 'PCR testing' named entity 'ILI' named entity 'influenza season' named entity 'RVI' named entity 'influenza infection' named entity 'CDC' named entity 'influenza vaccination'

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