About: Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study

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About: Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
Creator	Vincent, Jean-Louis Reinhart, Konrad Marshall, John Angus, Derek Bloos, Frank Balk, Robert Brunkhorst, Frank Laterre, Pierre-Francois Dellinger, Richard Gutierrez, Guillermo Rivers, Emanuel
Source	PMC
abstract	INTRODUCTION: The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia. METHODS: This was a multicenter, observational study of critically ill adult patients with pneumonia requiring mechanical ventilation conducted in 10 academic hospitals in Canada, the United States, and Central Europe. PCT was measured daily for 14 days using an immuno-luminometric assay. RESULTS: We included 175 patients, 57 with community acquired pneumonia (CAP), 61 with ventilator associated pneumonia (VAP) and 57 with hospital acquired pneumonia (HAP). Initial PCT levels were higher in CAP than VAP patients (median (interquartile range: IQR); 2.4 (0.95 to 15.8) vs. 0.7 (0.3 to 2.15), ng/ml, P < 0.001) but not significantly different to HAP (2.2 (0.4 to 8.0) ng/ml). The 28-day ICU mortality rate for all patients was 18.3% with a median ICU length of stay of 16 days (range 1 to 142 days). PCT levels were higher in non-survivors than in survivors. Initial and maximum PCT levels correlated with maximum Sequential Organ Failure Assessment (SOFA) score r(2 )= 0.50 (95% CI: 0.38 to 0.61) and r(2 )= 0.57 (0.46 to 0.66), respectively. Receiver operating curve (ROC) analysis on discrimination of 28-day mortality showed areas under the curve (AUC) of 0.74, 0.70, and 0.69 for maximum PCT, initial PCT, and Acute Physiology and Chronic Health Evaluation (APACHE) II score, respectively. The optimal cut-off to predict mortality for initial PCT was 1.1 ng/ml (odds ratio: OD 7.0 (95% CI 2.6 to 25.2)) and that for maximum PCT was 7.8 ng/ml (odds ratio 5.7 (95% CI 2.5 to 13.1)). CONCLUSIONS: PCT is associated with the severity of illness in patients with severe pneumonia and appears to be a prognostic marker of morbidity and mortality comparable to the APACHE II score.
has issue date	2011-03-07(xsd:dateTime)
bibo:doi	10.1186/cc10087
bibo:pmid	21385367
has license	cc-by
sha1sum (hex)	a059f73b05b6596bb14631d19a3511b7aef47e7d
schema:url	https://doi.org/10.1186/cc10087
resource representing a document's title	Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
has PubMed Central identifier	PMC3219347
has PubMed identifier	21385367
schema:publication	Crit Care
resource representing a document's body	covid:a059f73b05b6596bb14631d19a3511b7aef47e7d#body_text
is schema:about of	named entity 'Introduction' named entity 'SERUM' named entity 'PCT' named entity 'patients' named entity 'measured' named entity 'pneumonia' named entity 'serum' named entity 'observational study' named entity 'pleural fluid' named entity 'risk of death' named entity 'ROC' named entity 'organ dysfunction' named entity 'VAP' named entity 'pneumonia' named entity 'PSI' named entity 'risk factors' named entity 'ICU' named entity 'pneumonia' named entity 'intensive care unit' named entity 'VAP' named entity 'Odds ratios' named entity 'Pneumonia Severity Index' named entity 'ROC' named entity 'bronchoscopy' named entity 'cardiogenic shock' named entity 'VAP' named entity 'fever' named entity 'PSI' named entity 'procalcitonin' named entity 'clinical evidence' named entity 'odds ratio' named entity 'pneumonia' named entity 'pneumonia' named entity 'GCS' named entity 'ICU' named entity 'Food and Drug Administration' named entity 'expectoration' named entity 'pulmonary artery' named entity 'pneumonia' named entity 'sepsis' named entity '28 days' named entity 'mortality rate' named entity 'CAP' named entity 'Organ Failure' named entity 'CAP' named entity 'risk stratification' named entity 'infection' named entity 'mechanical ventilation' named entity 'pathogen' named entity 'tachypnea' named entity 'WBC' named entity 'crackles' named entity 'n.s.' named entity 'inflammation' named entity 'Physiology' named entity 'CAP' named entity 'VAP' named entity 'S. pneumoniae' named entity 'multivariate analyses' named entity 'community acquired pneumonia' named entity 'Organ dysfunction' named entity 'pneumonia' named entity 'VAP' named entity 'mechanical ventilation' named entity 'VAP' named entity 'CAP' named entity 'mechanically ventilated' named entity 'antimicrobial therapy' named entity 'acute respiratory distress syndrome' named entity 'percutaneous' named entity 'risk of death'

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