About: Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection
Creator	Arra, Manoj Bonenfant, Gaston Canki, Mario Fabris, Daniele Fuchs, Gabriele Henderson, Eric Miller, Clare Netzband, Rachel Biegel, Jason Pager, Cara Mcintyre, Will
Source	Medline; PMC
abstract	More than 140 post-transcriptional modifications (PTMs) are known to decorate cellular RNAs, but their incidence, identity and significance in viral RNA are still largely unknown. We have developed an agnostic analytical approach to comprehensively survey PTMs on viral and cellular RNAs. Specifically, we used mass spectrometry to analyze PTMs on total RNA isolated from cells infected with Zika virus, Dengue virus, hepatitis C virus (HCV), poliovirus and human immunodeficiency virus type 1. All five RNA viruses significantly altered global PTM landscapes. Examination of PTM profiles of individual viral genomes isolated by affinity capture revealed a plethora of PTMs on viral RNAs, which far exceeds the handful of well-characterized modifications. Direct comparison of viral epitranscriptomes identified common and virus-specific PTMs. In particular, specific dimethylcytosine modifications were only present in total RNA from virus-infected cells, and in intracellular HCV RNA, and viral RNA from Zika and HCV virions. Moreover, dimethylcytosine abundance during viral infection was modulated by the cellular DEAD-box RNA helicase DDX6. By opening the Pandora’s box on viral PTMs, this report presents numerous questions and hypotheses on PTM function and strongly supports PTMs as a new tier of regulation by which RNA viruses subvert the host and evade cellular surveillance systems.
has issue date	2018-06-20(xsd:dateTime)
bibo:doi	10.1093/nar/gky029
bibo:pmid	29373715
has license	cc-by-nc
sha1sum (hex)	a10019330d4147f613949ce0d30e0b0bc66499ea
schema:url	https://doi.org/10.1093/nar/gky029
resource representing a document's title	Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection
has PubMed Central identifier	PMC6009648
has PubMed identifier	29373715
schema:publication	Nucleic Acids Res
resource representing a document's body	covid:a10019330d4147f613949ce0d30e0b0bc66499ea#body_text
is schema:about of	named entity 'CELLULAR' named entity 'INCIDENCE' named entity 'VIRAL' named entity 'MORE THAN' named entity 'GLOBAL' named entity 'DEAD-BOX' named entity 'CELLULAR' named entity 'ISOLATED' named entity 'PRESENT' named entity 'EXAMINATION' named entity 'ZIKA' named entity 'KNOWN' named entity 'SURVEY' named entity 'DENGUE VIRUS' named entity 'OPENING' named entity 'USED' named entity 'VIRAL INFECTION' named entity 'ALTERED' named entity 'CHARACTERIZED' named entity 'ZIKA VIRUS' named entity 'FUNCTION' named entity 'HAVE' named entity 'VIRAL RNA' named entity 'IDENTIFIED' named entity 'APPROACH' named entity 'HEPATITIS C VIRUS' named entity 'UNKNOWN' named entity '27S' named entity 'PTM' named entity 'POLIOVIRUS' named entity 'NEW' named entity 'virions' named entity 'viral' named entity 'profiles' named entity 'RNA' named entity 'DEAD-box' named entity 'identity' named entity 'POSITIVE-SENSE RNA VIRUSES' named entity 'DIRECT' named entity 'HUMAN IMMUNODEFICIENCY VIRUS TYPE 1' named entity 'COMMON' covid:arg/a10019330d4147f613949ce0d30e0b0bc66499ea named entity 'TRANSCRIPTIONAL' named entity 'PLETHORA' named entity 'TIER' named entity 'FAR' named entity 'VIRAL' named entity 'INFECTION' named entity 'REVEAL' named entity 'DYNAMICS' named entity 'DDX6' named entity 'PARTICULAR' named entity 'RNA VIRUSES' named entity 'REGULATION' named entity 'LANDSCAPES' named entity 'LARGELY' named entity 'VIRAL AND' named entity 'INFECTED' named entity 'AGNOSTIC' named entity 'THEIR' named entity 'SPECIFIC' named entity 'IDENTITY' named entity 'POST' named entity 'SYSTEMS' named entity 'HCV' named entity 'COMPARISON' named entity 'MODULATED' named entity 'NUMEROUS' named entity 'RNAS' named entity 'SURVEILLANCE' named entity 'VIRUS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software