About: Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

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About: Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
Creator	De Clercq, Erik Naesens, Lieve Vázquez, Santiago López-Querol, Marta Camps, Pelayo Camins, Antoni Cortés, Diego Ivorra, Dolores Pallàs, Mercè Romero, Vanessa Duque, María Kelly, John Sureda, Francesc Prathalingam, S
source	Elsevier; Medline; PMC
abstract	Abstract The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed.
has issue date	2008-12-01(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2008.10.028
bibo:pmid	18954995
has license	els-covid
sha1sum (hex)	a1030b14be6fdd295b18de21525a37f0a0561444
schema:url	https://doi.org/10.1016/j.bmc.2008.10.028
resource representing a document's title	Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
has PubMed Central identifier	PMC7125889
has PubMed identifier	18954995
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:a1030b14be6fdd295b18de21525a37f0a0561444#body_text
is schema:about of	named entity 'PHARMACOLOGICAL' covid:arg/a1030b14be6fdd295b18de21525a37f0a0561444 named entity 'VIRUSES' named entity 'DIMETHYL' named entity 'REPORTED' named entity 'POLYCYCLIC' named entity 'INTERESTING' named entity 'THESE' named entity 'RIMANTADINE' named entity 'NMDA RECEPTOR ANTAGONISTS' named entity 'PHARMACOLOGY' named entity 'INHIBITED' named entity 'CONCENTRATION' named entity 'WIDE' named entity 'AMANTADINE' named entity 'CONTRACTED' named entity 'RING' named entity 'ANALOGUE' named entity 'ANALOGS' named entity 'SYNTHESIS' named entity 'RANGE' named entity 'SYNTHESIS' named entity 'EVALUATED' named entity 'SIMILAR' named entity 'EVALUATION' named entity 'INFLUENZA A VIRUS' named entity 'DOPAMINE UPTAKE' named entity 'THEIR' named entity 'NEW' named entity 'DISPLAYED' named entity '283' named entity 'ASSESSED' named entity 'ONE OF' named entity 'TRYPANOCIDAL ACTIVITY' named entity 'SIGNIFICANT' named entity 'AMINES' named entity 'AMANTADINE' named entity 'EFFECTS' named entity 'ACTIVITY' named entity 'dopamine' named entity 'amines' named entity 'amines' named entity 'pharmacology' named entity 'amantadine' named entity 'HAT' named entity 'mmol' named entity 'biologically active' named entity 'influenza virus' named entity 'EtOAc' named entity 'sindbis virus' named entity 'mmol' named entity 'KMnO' named entity 'mmol' named entity 'acetonitrile' named entity 'hexane' named entity 'mmol' named entity '12.2' named entity 'Curtius reaction' named entity 'mmol' named entity 'mmol' named entity 'KBr' named entity 'RNA viruses' named entity 'MeOH' named entity 'methylation' named entity 'rimantadine' named entity 'death rates' named entity 'crystallization' named entity 'amantadine'

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