About: Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

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About: Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19
Creator	Zhu, Yun Dogra, Pranay Horvat, Branka Mathieu, Cyrille Moscona, Anne Porotto, Matteo Connors, Thomas Farber, Donna Szabo, Peter Baldwin, Matthew Bitan, Zachary Bovier, Francesca Carpia, Francesca Chait, Michael Davis-Porada, Julia Decimo, Didier Ferrara, Stephen Gray, Joshua Hod, Eldad Idzikowski, Emma Lin, Wen-Hsuan Mace, Emily Matsumoto, Rei Meimei, Maya Milner, Joshua Poon, Li Weisberg, Stuart Wells, Steven Wontakal, Sandeep
source	MedRxiv; Medline
abstract	Clinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki's disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to adults with severe COVID-19 causing acute respiratory distress syndrome (ARDS), and those who recovered from mild disease. There was a reduced breadth and specificity of anti-SARS-CoV-2-specific antibodies in MIS-C patients compared to the COVID patient groups; MIS-C predominantly generated IgG Abs specific for the Spike (S) protein but not for the nucleocapsid (N) protein, while both COVID-19 cohorts had anti-S IgG, IgM and IgA Abs, as well as anti-N IgG Abs. Moreover, MIS-C patients had reduced neutralizing activity compared to COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children and adults who develop severe disease, with implications for optimizing treatments based on symptom and age.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1101/2020.07.12.20151068
bibo:pmid	32699861
has license	medrxiv
sha1sum (hex)	a1093a75a3734a5e9de029c5e68b6b90ef2aa2db
schema:url	https://doi.org/10.1101/2020.07.12.20151068
resource representing a document's title	Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19
has PubMed identifier	32699861
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:a1093a75a3734a5e9de029c5e68b6b90ef2aa2db#body_text
is schema:about of	named entity 'responses' named entity 'Antibody' named entity 'SARS-CoV2' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'inpatient setting' named entity 'ARDS' named entity 'virus' named entity 'multiple comparisons' named entity 'CO2' named entity 'control groups' named entity 'pseudovirus' named entity 'vaccines' named entity 'Mann-Whitney U test' named entity 'specific immune response' named entity 'MIS' named entity 'cell-based' named entity 'ANOVA' named entity 'COVID' named entity 'peer review' named entity '293T' named entity '1:50' named entity 'SARS-CoV-2' named entity 'infection' named entity 'peer review' named entity 'COVID' named entity 'expression vector' named entity 'MIS' named entity 'protein' named entity 'COVID' named entity 'Absorbance' named entity 'tested positive' named entity 'medRxiv' named entity 'MIS-C' named entity 'SARS-CoV-2' named entity 'mouse models' named entity 'virus' named entity 'fever' named entity 'plasma' named entity 'vector' named entity 'MIS-C' named entity 'ACE2' named entity 'MIS-C' named entity 'African green monkey' named entity 'ARDS' named entity 'Vero E6' named entity 'microneutralization' named entity 'medRxiv' named entity 'ectodomain' named entity 'SARS-Cov-2' named entity 'virus' named entity 'viral antigens' named entity 'Co-morbidities' named entity 'SARS-CoV-2'

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