About: Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection

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About: Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection
Creator	Banner, D Fang, Y Huang, Ssh Paquette, S Zhao, Z
Source	Medline; PMC
abstract	Pandemic H1N1 influenza A (H1N1pdm) is currently a dominant circulating influenza strain worldwide. Severe cases of H1N1pdm infection are characterized by prolonged activation of the immune response, yet the specific role of inflammatory mediators in disease is poorly understood. The inflammatory cytokine IL-6 has been implicated in both seasonal and severe pandemic H1N1 influenza A (H1N1pdm) infection. Here, we investigated the role of IL-6 in severe H1N1pdm infection. We found IL-6 to be an important feature of the host response in both humans and mice infected with H1N1pdm. Elevated levels of IL-6 were associated with severe disease in patients hospitalized with H1N1pdm infection. Notably, serum IL-6 levels associated strongly with the requirement of critical care admission and were predictive of fatal outcome. In C57BL/6J, BALB/cJ, and B6129SF2/J mice, infection with A/Mexico/4108/2009 (H1N1pdm) consistently triggered severe disease and increased IL-6 levels in both lung and serum. Furthermore, in our lethal C57BL/6J mouse model of H1N1pdm infection, global gene expression analysis indicated a pronounced IL-6 associated inflammatory response. Subsequently, we examined disease and outcome in IL-6 deficient mice infected with H1N1pdm. No significant differences in survival, weight loss, viral load, or pathology were observed between IL-6 deficient and wild-type mice following infection. Taken together, our findings suggest IL-6 may be a potential disease severity biomarker, but may not be a suitable therapeutic target in cases of severe H1N1pdm infection due to our mouse data.
has issue date	2012-06-05(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0038214
bibo:pmid	22679491
has license	cc-by
sha1sum (hex)	a234c5ac982ffc63b7be9d7c1b3473f92849192e
schema:url	https://doi.org/10.1371/journal.pone.0038214
resource representing a document's title	Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection
has PubMed Central identifier	PMC3367995
has PubMed identifier	22679491
schema:publication	PLoS One
resource representing a document's body	covid:a234c5ac982ffc63b7be9d7c1b3473f92849192e#body_text
is schema:about of	named entity 'severe' named entity 'serum' named entity 'activation' named entity 'IL-6' named entity 'INTERLEUKIN-6 ' named entity 'POTENTIAL' named entity 'DUE TO' named entity 'FEATURE' named entity 'REQUIREMENT' named entity 'ASSOCIATED WITH' named entity 'PANDEMIC' named entity 'IMMUNE RESPONSE' named entity 'CURRENTLY' named entity 'DEFICIENT' named entity 'ADMISSION' named entity 'TRIGGERED' named entity 'CIRCULATING' named entity 'OUTCOME' named entity 'BALB' named entity 'FINDINGS' named entity 'BIOMARKER' named entity 'ACTIVATION' named entity 'LETHAL' named entity 'MOUSE MODEL' named entity 'BUT' named entity 'HOSPITALIZED' named entity 'FOUND' named entity 'OBSERVED' named entity 'ASSOCIATED' named entity 'UNDERSTOOD' named entity 'WORLDWIDE' named entity 'OUR' named entity 'SEASONAL' named entity 'GLOBAL' named entity 'CHARACTERIZED' named entity 'PREDICTIVE' named entity 'IMPORTANT' named entity 'SEVERE DISEASE' named entity 'CRITICAL CARE' named entity 'HUMANS' named entity 'PROLONGED' named entity 'DISEASE SEVERITY' named entity 'EXAMINED' named entity 'MAY BE A' named entity 'DATA' named entity 'LEVELS' named entity 'VIRAL LOAD' named entity 'POORLY' named entity 'INFECTION' named entity 'WILD-TYPE' named entity 'IL-6' named entity 'MOUSE' named entity 'FOLLOWING' named entity 'MODEL OF' named entity 'INFLUENZA' named entity 'SIGNIFICANT' named entity 'PATHOLOGY' named entity 'IL-6 LEVELS' named entity 'DISEASE' named entity 'ROLE' named entity 'SUITABLE' named entity 'SEVERE' named entity 'DOMINANT' named entity 'THERAPEUTIC TARGET' named entity 'SUGGEST' named entity 'PANDEMIC' named entity 'SEVERE' named entity 'INFLUENZA A' named entity 'INFECTION' named entity 'BIOMARKER' named entity 'H1N1 INFLUENZA' named entity 'FATAL OUTCOME' named entity 'LUNG' named entity 'STRAIN' named entity 'HOST RESPONSE' named entity 'WEIGHT LOSS' named entity 'INDICATED'

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