About: An in-depth study of Crohn's disease in two French families

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An in-depth study of Crohn's disease in two French families
Creator	Cartun, R Colombel, J Cortot, A Devred, M Hoogkamp-Korstanje, J Kangro, " Koopmans, " Lecomte-Houcke, M Paris, J Van Kruiningen, H Whitlock, §
Source	Elsevier; Medline; PMC
abstract	Abstract Background: Two French families were investigated. In the first a husband, wife, and 4 children had Crohn's disease; in the second 7 of 11 children had the disease. There was no history of Crohn's disease in antecedent generations and no linkage to HLA haplotypes. Methods: Methods included family interviews; review of medical records, radiographs, and pathology slides; serology; selective stool culture; enzyme-linked immunosorbent assay for fecal viral detection; and immunocytochemistry. Results: In both families multiple cases occurred among siblings in 7–13-month periods. There appeared to be a 4–8-year recurrence of new disease in both families. Radiographs showed a remarkable similarity in the pattern of disease, confined to distal ileum and cecum, in the members of family 1. Examination for pathology showed granulomas in all 8 patients for whom tissues were available. Acid-fast organisms or Campylobacter-like organisms were not found in tissue sections, and immunocytochemistry was negative for mycobacteria and Yersinia. Stool cultures were negative for mycobacteria, Yersinia, and Mycoplasma. Torovirus and coronavirus antigens were not found in stool. Serology was negative for antibodies to Brucella, Yersinia, influenza, and three enteropathogenic viruses of animals. Conclusions: The circumstances and data suggest that an infectious microorganism is responsible for these clusterings of Crohn's disease.
has issue date	1993-02-28(xsd:dateTime)
bibo:doi	10.1016/0016-5085(93)90401-w
bibo:pmid	8425677
has license	els-covid
sha1sum (hex)	a3a361cf4aac50089e4c5bb414c72ec53c17659d
schema:url	https://doi.org/10.1016/0016-5085%2893%2990401-w
resource representing a document's title	An in-depth study of Crohn's disease in two French families
has PubMed Central identifier	PMC7130211
has PubMed identifier	8425677
schema:publication	Gastroenterology
resource representing a document's body	covid:a3a361cf4aac50089e4c5bb414c72ec53c17659d#body_text
is schema:about of	named entity 'radiographs' named entity 'Results' named entity 'Mycoplasma' named entity 'disease' named entity 'periods' named entity 'data' named entity 'Yersinia' named entity 'ileum' named entity 'tissues' covid:arg/a3a361cf4aac50089e4c5bb414c72ec53c17659d named entity 'responsible' named entity 'medical records' named entity 'members' named entity 'patients' named entity 'negative' named entity 'haplotypes' named entity 'serology' named entity 'similarity' named entity 'organisms' named entity 'disease' named entity 'cecum' named entity 'mycobacteria' named entity 'haplotypes' named entity 'pathology' named entity 'enteropathogenic' named entity 'influenza' named entity 'Mycoplasma' named entity 'Radiographs' named entity 'distal' named entity 'HLA' named entity 'Yersinia' named entity 'mycobacteria' named entity 'Crohn's disease' named entity 'serology' named entity 'viruses' named entity 'Yersinia' named entity 'stool' named entity 'organisms' named entity 'medical records' named entity 'enterocolitis' named entity 'Crohn's disease' named entity 'HLA' named entity 'immunocytochemistry' named entity 'Crohn's disease' named entity 'Yersinia' named entity 'Crohn's disease' named entity 'enzyme-linked immunosorbent assay' named entity 'cecum' named entity 'Serology' named entity 'pathology' named entity 'Radiographic' named entity 'Yersinia' named entity 'antigens' named entity 'pathogens' named entity 'Acid-fast' named entity 'immunocytochemistry' named entity 'ileal' named entity 'pathology' named entity 'enteropathogenic' named entity 'family 1' named entity 'colon' named entity 'mice' named entity 'Crohn's disease' named entity 'pathogen' named entity 'influenza' named entity 'Crohn's disease' named entity 'antibodies' named entity 'mycobacteria' named entity 'Crohn's disease' named entity 'Mycoplasma' named entity 'Stool cultures'

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