About: Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity

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About: Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
Creator	Agrawal, Anshu Agrawal, Sudhanshu Gupta, Sudhir Esposo, Marc Kaushal, Khushboo Osann, Kathyrn Sridharan, Aishwarya Tay, Jia
Source	Medline; PMC
abstract	Increased susceptibility to infections, particularly respiratory viral infections, is a hallmark of advancing age. The underlying mechanisms are not well understood, and there is a scarcity of information regarding the contribution of the innate immune system, which is the first line of defense against infections. In the present study, we have investigated the effect of advancing age on plasmacytoid dendritic cell (PDC) function because they are critical in generating a robust antiviral response via the secretion of interferons (IFN). Our results indicate that PDCs from the aged are impaired in their capacity to secrete IFN-I in response to influenza virus and CPG stimulation. Additionally, we observed a severe reduction in the production of IFN-III, which plays an important role in defense against viral infections at respiratory mucosal surfaces. This reduction in IFN-I and IFN-III were a result of age-associated impaired phosphorylation of transcription factor, IRF-7. Furthermore, aged PDCs were observed to be impaired in their capacity to induce perforin and granzyme in CD8 T cells. Comparison of the antigen-presenting capacity of aged PDC with young PDC revealed that PDCs from aged subjects display reduced capacity to induce proliferation and IFN-gamma secretion in CD4 and CD8 T cells as compared with PDCs from young subjects. In summary, our study demonstrates that advancing age has a profound effect on PDC function at multiple levels and may therefore, be responsible for the increased susceptibility to infections in the elderly.
has issue date	2010-10-16(xsd:dateTime)
bibo:doi	10.1007/s11357-010-9191-3
bibo:pmid	20953722
has license	no-cc
sha1sum (hex)	a43bb56b5b1f3c5d5f30023ce701f33d670bc5ce
schema:url	https://doi.org/10.1007/s11357-010-9191-3
resource representing a document's title	Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
has PubMed Central identifier	PMC3168606
has PubMed identifier	20953722
schema:publication	Age (Dordr)
resource representing a document's body	covid:a43bb56b5b1f3c5d5f30023ce701f33d670bc5ce#body_text
is schema:about of	named entity 'DECREASED' named entity 'CELL FUNCTIONS' named entity 'CRITICAL' named entity 'PLASMACYTOID DENDRITIC CELL' named entity 'INNATE IMMUNE SYSTEM' named entity 'FUNCTION' named entity 'ADVANCING' named entity 'MECHANISMS' named entity 'ROBUST' named entity 'STUDY' named entity 'INFECTIONS' named entity 'INTERFERONS' named entity 'GENERATING' named entity 'ANTIVIRAL RESPONSE' covid:arg/a43bb56b5b1f3c5d5f30023ce701f33d670bc5ce named entity 'IMPAIRED' named entity 'INFORMATION' named entity 'DEFENSE' named entity 'UNDERLYING' named entity 'CONTRIBUTION' named entity 'NOT WELL' named entity 'IS A' named entity 'LEAD' named entity 'PLASMACYTOID DENDRITIC CELL' named entity 'CD8' named entity 'UNDERSTOOD' named entity 'EFFECT' named entity 'ASSOCIATED' named entity 'CD4' named entity 'T CELL IMMUNITY' named entity 'PRESENT' named entity 'AGE' named entity 'LINE' named entity 'INCREASED SUSCEPTIBILITY TO INFECTIONS' named entity 'HAVE' named entity 'RESPIRATORY' named entity 'SECRETION' named entity 'AGE' named entity 'VIRAL INFECTIONS' named entity 'INVESTIGATED' named entity 'plasmacytoid dendritic cell' named entity 'Age-associated' named entity 'CD4' named entity 'granzyme' named entity 'adversely affect' named entity 'innate immune' named entity 'cytokine secretion' named entity 'PDCs' named entity 'influenza virus' named entity 'PDCs' named entity 'Plasmacytoid dendritic cells' named entity 'secretion' named entity 'TLR' named entity 'secretion' named entity 'viral infections' named entity 'MyD88' named entity 'influenza' named entity 'Cella' named entity 'MHC' named entity 'Bar graph' named entity 'receptor' named entity 'lysed' named entity 'IFN' named entity 'IP-10' named entity 'respiratory infections' named entity 'class II' named entity 'mucosal' named entity 'Flu' named entity 'CD8 T cells' named entity 'SARS' named entity 'influenza virus' named entity 'PDCs' named entity 'PDCs' named entity 'PDCs'

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