About: Inhibition of Tetraspanin Functions Impairs Human Papillomavirus and Cytomegalovirus Infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of Tetraspanin Functions Impairs Human Papillomavirus and Cytomegalovirus Infections
Creator	Sinzger, Christian Boukhallouk, Fatima Florin, Luise Fritzen, Anna Hochdorfer, Daniel Lieber, Diana Mikuličić, Snježana Schwickert, Jonas Suarez, Henar Yáñez-Mó, María Fast, Laura Monk, Peter
source	PMC
abstract	Tetraspanins are suggested to regulate the composition of cell membrane components and control intracellular transport, which leaves them vulnerable to utilization by pathogens such as human papillomaviruses (HPV) and cytomegaloviruses (HCMV) to facilitate host cell entry and subsequent infection. In this study, by means of cellular depletion, the cluster of differentiation (CD) tetraspanins CD9, CD63, and CD151 were found to reduce HPV16 infection in HeLa cells by 50 to 80%. Moreover, we tested recombinant proteins or peptides of specific tetraspanin domains on their effect on the most oncogenic HPV type, HPV16, and HCMV. We found that the C-terminal tails of CD63 and CD151 significantly inhibited infections of both HPV16 and HCMV. Although CD9 was newly identified as a key cellular factor for HPV16 infection, the recombinant CD9 C-terminal peptide had no effect on infection. Based on the determined half-maximal inhibitory concentration (IC(50)), we classified CD63 and CD151 C-terminal peptides as moderate to potent inhibitors of HPV16 infection in HeLa and HaCaT cells, and in EA.hy926, HFF (human foreskin fibroblast) cells, and HEC-LTT (human endothelial cell-large T antigen and telomerase) cells for HCMV, respectively. These results indicate that HPV16 and HCMV share similar cellular requirements for their entry into host cells and reveal the necessity of the cytoplasmic CD151 and CD63 C-termini in virus infections. Furthermore, this highlights the suitability of these peptides for functional investigation of tetraspanin domains and as inhibitors of pathogen infections.
has issue date	2018-10-02(xsd:dateTime)
bibo:doi	10.3390/ijms19103007
bibo:pmid	30279342
has license	cc-by
sha1sum (hex)	a43db4dbbe6272ff71bcd5dc9cbf29bad9cd958e
schema:url	https://doi.org/10.3390/ijms19103007
resource representing a document's title	Inhibition of Tetraspanin Functions Impairs Human Papillomavirus and Cytomegalovirus Infections
has PubMed Central identifier	PMC6212908
has PubMed identifier	30279342
schema:publication	Int J Mol Sci
resource representing a document's body	covid:a43db4dbbe6272ff71bcd5dc9cbf29bad9cd958e#body_text
is schema:about of	named entity 'CD63' named entity 'infection' named entity 'factor' named entity 'infections' named entity 'C-terminal' named entity 'HPV' named entity 'Inhibition' named entity 'Cytomegalovirus' named entity 'INHIBITION' named entity 'PATHOGENS' named entity 'TETRASPANIN' named entity 'IDENTIFIED' named entity 'SUBSEQUENT' named entity 'LEAVES' named entity 'MODERATE' named entity 'ENDOTHELIAL CELL' named entity 'CD9' named entity 'CYTOPLASMIC' named entity 'RECOMBINANT' named entity 'THESE' named entity 'CELLULAR' named entity 'INHIBITORS' named entity 'INFECTIONS' named entity 'NEWLY' named entity 'INFECTION' named entity 'PEPTIDES' named entity 'KEY' named entity 'AS INHIBITORS' named entity 'VULNERABLE' named entity 'COMPONENTS' named entity 'SIMILAR' named entity 'CONCENTRATION' named entity 'PATHOGEN' named entity 'CYTOMEGALOVIRUS INFECTIONS' named entity 'TETRASPANIN' named entity 'CELLS' named entity 'NO EFFECT' named entity 'ENTRY' named entity 'CD151' named entity 'CELL MEMBRANE' named entity '80%' named entity 'NECESSITY' named entity 'IMPAIRS' named entity 'FUNCTIONS' named entity 'FORESKIN FIBROBLAST' named entity 'INTRACELLULAR TRANSPORT' named entity 'DETERMINED' named entity 'HELA' named entity 'CLUSTER OF DIFFERENTIATION' named entity 'TO REGULATE' named entity 'HPV TYPE' named entity 'STUDY' named entity 'MEANS' named entity 'RECOMBINANT PROTEINS' named entity 'THEIR' named entity 'HACAT' named entity 'EFFECT' named entity 'TAILS' named entity 'TETRASPANINS' named entity 'LARGE T ANTIGEN' named entity 'TESTED' named entity 'ENTRY INTO HOST' named entity 'FACTOR' named entity 'TELOMERASE' named entity 'COMPOSITION' named entity 'RESULTS' named entity 'CLASSIFIED' named entity 'HCMV' named entity 'SHARE' named entity 'HPV16 INFECTION'

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