About: Biosafety steps in the manufacturing process of spray-dried plasma: a review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedure

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Biosafety steps in the manufacturing process of spray-dried plasma: a review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedure Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Biosafety steps in the manufacturing process of spray-dried plasma: a review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedure
Creator	Polo, Javier Segalés, Joaquim Pujols, Joan Rodríguez, Carmen Ródenas, Jesús Blázquez, Elena
source	Medline; PMC
abstract	Spray dried plasma (SDP) is a functional protein source obtained from blood of healthy animals, approved by the veterinary authorities from animals declared to be fit for slaughter for human consumption. Blood of these animals is collected at the slaughterhouse, treated with an anticoagulant, chilled and transported to industrial facilities in which blood is centrifuged to separate the red blood cells from the plasma fraction. Plasma is then concentrated, and spray dried at high temperatures (80 °C throughout its substance) to convert it in a powder. Such method preserves the biological activity of its proteins, mainly albumins and globulins. SDP is mainly used in pig feed diets to significantly improve daily gain, feed intake, production efficiency, and to reduce post-weaning lag caused by the appearance of post-weaning diarrhea. Although SDP is considered a safe product and its manufacturing process consists of several biosafety steps, the security of the SDP is often questioned due to its nature as raw blood by-product, especially when emergent or re-emergent pathogens appear. This review provides an evaluation and validation of the different safety steps present in the manufacturing process of SDP, with special focus on a new redundant pathogen inactivation step, the UV-C irradiation, that may be implemented in the manufacturing process of the SDP. Overall results showed that the manufacturing process of SDP is safe and the UV-C radiation was effective in inactivating a wide range of bacteria and viruses spiked and naturally present in commercially collected liquid animal plasma and it can be implemented as a redundant biosafety step in the manufacturing process of the SDP.
has issue date	2020-07-16(xsd:dateTime)
bibo:doi	10.1186/s40813-020-00155-1
bibo:pmid	32690994
has license	cc-by
sha1sum (hex)	a5361f5b33f4bfb78ffa8b94023305ec20e91e45
schema:url	https://doi.org/10.1186/s40813-020-00155-1
resource representing a document's title	Biosafety steps in the manufacturing process of spray-dried plasma: a review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedure
has PubMed Central identifier	PMC7363457
has PubMed identifier	32690994
schema:publication	Porcine Health Manag
resource representing a document's body	covid:a5361f5b33f4bfb78ffa8b94023305ec20e91e45#body_text
is schema:about of	named entity 'separate' named entity 'fit' named entity 'liquid' named entity 'diarrhea' named entity 'plasma' named entity 'slaughterhouse' named entity 'concentrated' named entity 'process' named entity 'EFFICIENCY' named entity 'BACTERIA ' named entity 'LIQUID' named entity 'VIRUSES' named entity 'SPECIAL' named entity 'ANTICOAGULANT' named entity 'declared' named entity 'evaluation' named entity 'functional' named entity 'product' named entity 'temperatures' named entity 'globulins' named entity 'treated' named entity 'by-product' named entity 'chilled' named entity 'caused' named entity 'protein' named entity 'animal' named entity 'manufacturing' named entity 'consumption' named entity 'daily' named entity 'bacteria' named entity 'biosafety' named entity 'naturally' named entity 'commercially' named entity 'albumins' named entity 'centrifuged' named entity 'UV-C' named entity 'slaughterhouse' named entity 'globulins' named entity 'biosafety' named entity 'human consumption' named entity 'by-product' named entity 'biosafety' named entity 'dried plasma' named entity 'viruses' named entity 'porcine' named entity 'bacteria' named entity 'damage to DNA' named entity 'Bovine viral diarrhea virus' named entity 'plasma' named entity 'reverse osmosis' named entity 'nanofiltration' named entity 'viruses' named entity 'membrane filtration' named entity 'abattoir' named entity 'abattoirs' named entity 'water activity' named entity 'Blood collection' named entity 'human food' named entity 'spray drying' named entity 'biohazards' named entity 'centrifuged' named entity 'Enveloped viruses' named entity 'microbial' named entity 'steel pan' named entity 'nucleic acids' named entity 'animal model' named entity 'spray-drying' named entity 'plasma' named entity 'bioassay' named entity 'blood products' named entity 'Vero cells' named entity 'bacteria' named entity 'Plasma' named entity 'high-quality' named entity 'plasma' named entity 'animal health'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software