About: SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets

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About: SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets
Creator	Canard, Bruno Decroly, Etienne Coutard, Bruno Ferron, François Imbert, Isabelle Subissi, Lorenzo Collet, Axelle
source	Elsevier; Medline; PMC
abstract	Abstract The SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replication-transcription complex (RTC). The RTC directs and coordinates processes in order to replicate and transcribe the coronavirus genome, a single-stranded, positive-sense RNA of outstanding length (∼27–32kilobases). Here, we review the up-to-date knowledge on SARS-CoV replicative enzymes encoded in the ORF1b, i.e., the main RNA-dependent RNA polymerase (nsp12), the helicase/triphosphatase (nsp13), two unusual ribonucleases (nsp14, nsp15) and RNA-cap methyltransferases (nsp14, nsp16). We also review how these enzymes co-operate with other viral co-factors (nsp7, nsp8, and nsp10) to regulate their activity. These last ten years of research on SARS-CoV have considerably contributed to unravel structural and functional details of one of the most fascinating replication/transcription machineries of the RNA virus world. This paper forms part of a series of invited articles in Antiviral Research on “From SARS to MERS: 10years of research on highly pathogenic human coronaviruses”.
has issue date	2014-01-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2013.11.006
bibo:pmid	24269475
has license	els-covid
sha1sum (hex)	a5d0b34f30d76d6f680291733e307106bd40078d
schema:url	https://doi.org/10.1016/j.antiviral.2013.11.006
resource representing a document's title	SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets
has PubMed Central identifier	PMC7113864
has PubMed identifier	24269475
schema:publication	Antiviral Research
resource representing a document's body	covid:a5d0b34f30d76d6f680291733e307106bd40078d#body_text
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