About: The Aging of γδ T Cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Aging of γδ T Cells
Creator	Fulop, Tamas Larbi, Anis Xu, Weili Lau, Xuan Wan, Zandrea
Source	Medline; PMC
abstract	In the coming decades, many developed countries in the world are expecting the “greying” of their populations. This phenomenon poses unprecedented challenges to healthcare systems. Aging is one of the most important risk factors for infections and a myriad of diseases such as cancer, cardiovascular and neurodegenerative diseases. A common denominator that is implicated in these diseases is the immune system. The immune system consists of the innate and adaptive arms that complement each other to provide the host with a holistic defense system. While the diverse interactions between multiple arms of the immune system are necessary for its function, this complexity is amplified in the aging immune system as each immune cell type is affected differently—resulting in a conundrum that is especially difficult to target. Furthermore, certain cell types, such as γδ T cells, do not fit categorically into the arms of innate or adaptive immunity. In this review, we will first introduce the human γδ T cell family and its ligands before discussing parallels in mice. By covering the ontogeny and homeostasis of γδ T cells during their lifespan, we will better capture their evolution and responses to age-related stressors. Finally, we will identify knowledge gaps within these topics that can advance our understanding of the relationship between γδ T cells and aging, as well as age-related diseases such as cancer.
has issue date	2020-05-09(xsd:dateTime)
bibo:doi	10.3390/cells9051181
bibo:pmid	32397491
has license	cc-by
sha1sum (hex)	a5d192e906bb83dbbb49af0da75f87c8bac76c5c
schema:url	https://doi.org/10.3390/cells9051181
resource representing a document's title	The Aging of γδ T Cells
has PubMed Central identifier	PMC7290956
has PubMed identifier	32397491
schema:publication	Cells
resource representing a document's body	covid:a5d192e906bb83dbbb49af0da75f87c8bac76c5c#body_text
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