About: CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations

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About: CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations
Creator	Johnston, Sebastian Haas, J Rohde, G Johnston, S Mallia, P Edwards, M Kebadze, T Khaitov, M Kon, O Laza-Stanca, V Message, S Parker, H Stanciu, L
source	Medline; PMC
abstract	RATIONALE: Rhinoviruses (RVs) are the major triggers of asthma exacerbations. We have shown previously that lower respiratory tract symptoms, airflow obstruction, and neutrophilic airway inflammation were increased in experimental RV‐induced asthma exacerbations. OBJECTIVES: We hypothesized that neutrophil‐related CXC chemokines and antimicrobial peptides are increased and related to clinical, virologic, and pathologic outcomes in RV‐induced exacerbations of asthma. METHODS: Protein levels of antimicrobial peptides (SLPI, HNP 1–3, elafin, and LL‐37) and neutrophil chemokines (CXCL1/GRO‐α, CXCL2/GRO‐β, CXCL5/ENA‐78, CXCL6/GCP‐2, CXCL7/NAP‐2, and CXCL8/IL‐8) were determined in bronchoalveolar lavage (BAL) fluid of 10 asthmatics and 15 normal controls taken before, at day four during and 6 weeks post‐experimental infection. RESULTS: BAL HNP 1–3 and Elafin were higher, CXCL7/NAP‐2 was lower in asthmatics compared with controls at day 4 (P = 0.035, P = 0.048, and P = 0.025, respectively). BAL HNP 1–3 and CXCL8/IL‐8 were increased during infection (P = 0.003 and P = 0.011, respectively). There was a trend to increased BAL neutrophils at day 4 compared with baseline (P = 0.076). BAL HNP 1–3 was positively correlated with BAL neutrophil numbers at day 4. There were no correlations between clinical parameters and HNP1–3 or IL‐8 levels. CONCLUSIONS: We propose that RV infection in asthma leads to increased release of CXCL8/IL‐8, attracting neutrophils into the airways where they release HNP 1–3, which further enhances airway neutrophilia. Strategies to inhibit CXCL8/IL‐8 may be useful in treatment of virus‐induced asthma exacerbations.
has issue date	2014-06-23(xsd:dateTime)
bibo:doi	10.1111/cea.12313
bibo:pmid	24673807
has license	cc-by
sha1sum (hex)	a613d8d7267d15c258be90a313a47fd2f83f4a6d
schema:url	https://doi.org/10.1111/cea.12313
resource representing a document's title	CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations
has PubMed Central identifier	PMC4403958
has PubMed identifier	24673807
schema:publication	Clin Exp Allergy
resource representing a document's body	covid:a613d8d7267d15c258be90a313a47fd2f83f4a6d#body_text
is schema:about of	named entity 'neutrophil' named entity 'CXCL8' named entity 'numbers' named entity 'fluid' named entity 'controls' named entity 'INCREASED' named entity 'CXCL7' named entity 'LOWER' named entity 'infection' named entity 'hypothesized' named entity 'levels' named entity 'HNP' named entity 'higher' named entity 'chemokines' named entity 'experimental' named entity 'asthma exacerbations' named entity 'neutrophils' named entity 'neutrophil' named entity 'CXCL8/IL-8' named entity 'infection' named entity 'inflammation' named entity 'neutrophil' named entity 'asthmatics' named entity 'CXCL7' named entity 'CXCL8/IL-8' named entity 'positively correlated' named entity 'LL-37' named entity 'HNP1' named entity 'antimicrobial peptides' named entity 'CXC chemokines' named entity 'CXCL8/IL-8' named entity 'infection' named entity 'asthmatics' named entity 'asthmatic' named entity 'antimicrobial peptide' named entity 'viruses' named entity 'non-atopic' named entity 'defensins' named entity 'asthmatics' named entity 'PEF' named entity 'neutrophilic' named entity 'atomizer' named entity 'asthmatic' named entity 'nasal lavage' named entity 'asthmatic' named entity 'infection' named entity 'Th1' named entity 'asthmatic' named entity 'ng/mL' named entity 'neutrophil' named entity 'asthma exacerbations' named entity 'bronchoscopy' named entity 'non-normally distributed' named entity 'non-normally distributed' named entity 'neutrophil' named entity 'respiratory epithelial cell' named entity 'IgE' named entity 'virus' named entity 'CD4 +' named entity 'defensins' named entity 'neutrophils' named entity 'asthma' named entity 'lung function testing' named entity 'viral load' named entity 'CXCL7' named entity 'lower respiratory tract' named entity 'infection' named entity 'inflammatory mediators' named entity 'Neutrophils'

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