About: PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze

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About: PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze
Creator	Hedlin, Gunilla Papadopoulos, Nikolaos Ebner, Daniel Gallerano, Daniela Harwanegg, Christian Lupinek, Christian Megremis, Spyridon Napora-Wijata, Kamila Niespodziana, Katarzyna Schlederer, Thomas Stenberg-Hammar, Katarina Söderhäll, Cilla Valenta, Rudolf Cabauatan, Clarissa Vacal, Phyllis Van Hage, Marianne
source	Medline; PMC
abstract	Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of virus type-specific treatment strategies. Here, we develop a chip containing 130 different micro-arrayed RV proteins and peptides and demonstrate in a cohort of 120 pre-school children, most of whom had been hospitalized due to acute wheeze, that it is possible to determine the culprit RV species with a minute blood sample by serology. Importantly, we identify RV-A and RV-C species as giving rise to most severe respiratory symptoms. Thus, we have generated a chip for the serological identification of RV-induced respiratory illness which should be useful for the rational development of preventive and therapeutic strategies targeting the most important RV types.
has issue date	2018-06-18(xsd:dateTime)
bibo:doi	10.1038/s41467-018-04591-0
bibo:pmid	29915220
has license	cc-by
sha1sum (hex)	a6d78920011473fe481d4fc46e9ba4535332b87c
schema:url	https://doi.org/10.1038/s41467-018-04591-0
resource representing a document's title	PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze
has PubMed Central identifier	PMC6006174
has PubMed identifier	29915220
schema:publication	Nat Commun
resource representing a document's body	covid:a6d78920011473fe481d4fc46e9ba4535332b87c#body_text
is schema:about of	named entity 'asthma' named entity 'types' named entity 'virus' named entity 'PRE-SCHOOL' named entity 'RHINOVIRUS' named entity 'VIRUS TYPE' named entity 'POSSIBLE' named entity '120' named entity 'SEROLOGICAL' named entity 'SCHOOL CHILDREN' named entity 'HOSPITALIZED' named entity 'HERE' named entity 'OCCURRENCE' named entity 'CHIP' named entity 'TARGETING' named entity 'SPECIFIC' named entity 'THERAPEUTIC' named entity 'MINUTE' named entity 'PREVENTIVE' named entity 'SPECIES' named entity 'RESPIRATORY SYMPTOMS' named entity 'DEVELOPMENT' named entity 'RESPIRATORY DISEASES' named entity 'SEROLOGY' named entity 'IDENTIFICATION' named entity 'MICRO-' named entity 'DETERMINE' named entity 'GIVING' named entity 'ASTHMA' named entity 'RESPIRATORY ILLNESS' named entity 'TYPES' named entity 'INDUCED' named entity 'BASED' named entity 'MOST OF' named entity 'TREATMENT' named entity 'INDUCED' named entity 'DIAGNOSIS' named entity 'ACUTE EXACERBATIONS' named entity 'WHEEZE' named entity 'VIRUS TYPES' named entity 'CHIP' named entity 'RHINOVIRUS' named entity 'USEFUL' named entity 'BLOOD SAMPLE' named entity 'ACUTE' named entity 'IMPROVEMENT' named entity 'IDENTIFY' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'IS A' named entity 'PROTEINS' named entity 'STRATEGIES' named entity 'PEPTIDES' named entity 'RISE' named entity 'GENERATED' named entity 'MAJOR' named entity 'HAVE' named entity 'SEVERE' named entity 'DUE TO' named entity 'INFECTIONS' named entity 'CONTAINING' named entity 'TRIGGERS' named entity 'HIGH RESOLUTION' named entity 'NUMEROUS' named entity 'WHEEZE' named entity 'COHORT' named entity '130'

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