About: Characterization of the 3a Protein of SARS-associated Coronavirus in Infected Vero E6 Cells and SARS Patients

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About: Characterization of the 3a Protein of SARS-associated Coronavirus in Infected Vero E6 Cells and SARS Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of the 3a Protein of SARS-associated Coronavirus in Infected Vero E6 Cells and SARS Patients
Creator	Wang, Yuan Zhang, Xi Zhang, Lei Wang, Jin Sun, Bing Lin, Ying Ji, Yong-Yong Wang, Xiao-Yi Wu, Xiao-Dong Yang, Rui-Fu Cao, Ju-Tian Chen, Song-Hua Dai, Er-Hei Gan, Yong-Hua Jiang, Man-Rong Jiang, Xiao-Sheng Jiang, Zhi-Qin Jin, Yan Li, Yu-Chuan Ruan, Hong-Qiang Shan, Shi-Fang Shi, Lv Shi, Mu-De Wang, Cui-E Wang, Hong-Xia Wu, Jia-Rui Xie, En Xie, You-Hua Xiong, Lei Zeng, Rong Zhou, Hu Zuo, Jiang-Ping Si, Ying
source	Elsevier; Medline; PMC
abstract	Abstract Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment.
has issue date	2004-07-30(xsd:dateTime)
bibo:doi	10.1016/j.jmb.2004.06.016
bibo:pmid	15312778
has license	els-covid
sha1sum (hex)	a6f22a112e9afb2dc689796dd434cd226e63b03e
schema:url	https://doi.org/10.1016/j.jmb.2004.06.016
resource representing a document's title	Characterization of the 3a Protein of SARS-associated Coronavirus in Infected Vero E6 Cells and SARS Patients
has PubMed Central identifier	PMC7127270
has PubMed identifier	15312778
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:a6f22a112e9afb2dc689796dd434cd226e63b03e#body_text
is schema:about of	named entity 'patients' named entity 'SARS-CoV' named entity 'Patients' named entity 'TENDENCY' named entity 'TO IDENTIFY' named entity 'SIGNIFICANT' named entity 'SPIKE PROTEIN' named entity 'MUTATION' named entity 'INDICATED' named entity 'REACTIONS' named entity 'REVEALED' named entity 'FUNCTION' named entity 'PROTEIN' named entity 'SERA' named entity 'SERVE' named entity 'FUNCTIONS' named entity 'PATIENTS' named entity 'SARS-COV' named entity 'VERO' named entity 'DISULFIDE BONDS' named entity 'PEPTIDE' covid:arg/a6f22a112e9afb2dc689796dd434cd226e63b03e named entity 'PATIENTS' named entity 'CELLS' named entity 'PROTEIN ' named entity 'ENCODED' named entity 'ELISA' named entity 'CONCORDANT' named entity 'SARS' named entity 'MIGHT BE' named entity 'ISOLATES' named entity 'HAVE' named entity 'CLINICAL MARKER' named entity 'DERIVED' named entity 'DRUG TARGET' named entity 'BLOTTING' named entity 'A PROTEIN' named entity 'SARS' named entity 'PROTEIN ' named entity 'POSITIVE' named entity 'USED' named entity 'THESE' named entity 'FORMED' named entity 'TAKEN' named entity 'CORRELATED' named entity 'PROTEOMICS' named entity 'ORF' named entity 'RESULTS' named entity 'PEPTIDES'

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