About: Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis

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About: Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis
Creator	Jiang, Chengyu Wang, Hongliang
Source	Medline; PMC
abstract	Influenza A virus H5N1 presents a major threat to human health. The entry of influenza virus into host cells is believed to be mediated by hemagglutinin (HA), a virus surface glycoprotein that can bind terminal sialic acid residues on host cell glycoproteins and glycolipids. In this study, we elucidated the pathways through which H5N1 enters human lung carcinoma cell line A549. We first proved that H5N1 can enter A549 cells via endocytosis, as lysosomotropic agents, such as bafilomycin A1 and chloroquine, can rescue H5N1-induced A549 cell death. By using specific inhibitors, and siRNAs that target the clathrin pathway, we further found that H5N1 could enter A549 cells via clathrin-mediated endocytosis, while inhibitors targeting caveolae-mediated endocytosis could not inhibit H5N1 cell entry. These findings expand our understanding of H5N1 pathogenesis and provide new information for anti-viral drug research.
has issue date	2009-05-27(xsd:dateTime)
bibo:doi	10.1007/s11427-009-0061-0
bibo:pmid	19471869
has license	no-cc
sha1sum (hex)	a74b31aec3c6b3b38d5c35bc19a8077121029cd9
schema:url	https://doi.org/10.1007/s11427-009-0061-0
resource representing a document's title	Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis
has PubMed Central identifier	PMC7089391
has PubMed identifier	19471869
schema:publication	Sci China C Life Sci
resource representing a document's body	covid:a74b31aec3c6b3b38d5c35bc19a8077121029cd9#body_text
is schema:about of	named entity 'chloroquine' named entity 'residues' named entity 'Influenza A virus' named entity 'virus' named entity 'pathogenesis' named entity 'mediated' named entity 'influenza' named entity 'inhibit' named entity 'HOST CELLS' named entity 'H5N1' named entity 'FINDINGS' named entity 'PRESENTS' named entity 'H5N1' named entity 'TARGETING' named entity 'UNDERSTANDING' named entity 'GLYCOLIPIDS' named entity 'SIALIC ACID' named entity 'CHLOROQUINE' named entity 'OUR' named entity 'CELL DEATH' named entity 'HUMAN LUNG' named entity 'DRUG RESEARCH' named entity 'INFLUENZA VIRUS' named entity 'CELL' named entity 'A549 CELLS' named entity 'HUMAN HEALTH' named entity 'HEMAGGLUTININ' named entity 'ENTRY INTO HOST' named entity 'INFLUENZA A VIRUS' named entity 'LUNG CARCINOMA CELL LINE' named entity 'FOUND' named entity 'ENDOCYTOSIS' named entity 'A549' named entity 'INFLUENZA A VIRUS' named entity 'SIRNAS' named entity 'VIRUS' named entity 'ENTRY' named entity 'EXPAND' named entity 'HOST CELLS' named entity 'USING' named entity 'SPECIFIC' named entity 'INDUCED' named entity 'ANTI-VIRAL DRUG' named entity 'ENTER' named entity 'PROVIDE' named entity 'CLATHRIN-DEPENDENT ENDOCYTOSIS' named entity 'THESE' named entity 'PATHWAYS' named entity 'TARGET' named entity 'HOST CELL' named entity 'RESCUE' named entity 'INHIBITORS' named entity 'GLYCOPROTEINS' named entity 'MEDIATED' named entity 'BIND' named entity 'NEW INFORMATION' named entity 'THREAT' named entity 'BAFILOMYCIN A1' named entity 'A MAJOR' named entity 'CLATHRIN-MEDIATED ENDOCYTOSIS' named entity 'TERMINAL' named entity 'CAVEOLAE-MEDIATED ENDOCYTOSIS' named entity 'CLATHRIN PATHWAY' named entity 'PATHOGENESIS' named entity 'A549 CELL' named entity 'STUDY' named entity 'study' named entity 'anti-viral drug' named entity 'endocytosis' named entity 'endocytosis' named entity 'cell membrane' named entity 'endocytic' named entity 'carcinoma' named entity 'H5N1' named entity 'clathrin-dependent endocytosis' named entity 'siRNAs' named entity 'host cell' named entity 'endocytosis' named entity 'glycolipids' named entity 'chloroquine'

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