About: Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection

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About: Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection
Creator	Mejias, Asuncion Ramilo, Octavio Moore-Clingenpeel, Melissa Cohen, Daniel Garcia-Mauriño, Cristina Mertz, Sara Thomas, Jessica
source	Medline; PMC
abstract	BACKGROUND: The association between respiratory syncytial virus (RSV) loads and clinical outcomes in children remains to be defined. In most studies, viral loads (VL) were evaluated in hospitalized children and at a single time-point. We investigated the relationship between VLs and disease severity in both outpatients and inpatients with RSV infection. METHODS: We enrolled previously healthy children with RSV infection. Disease severity was defined by level of care (outpatients vs ward vs pediatric intensive care unit [PICU]), and a clinical disease severity score (CDSS). Nasopharyngeal VLs by polymerase chain reaction and CDSS were measured at enrollment and daily in inpatients. VL decay according to disease severity was analyzed using linear mixed modeling. RESULTS: From February 2015 to March 2017, we enrolled 150 infants: 39 outpatients and 111 inpatients. VLs were higher in outpatients than in age-matched inpatients. Among inpatients, initial VLs were comparable in ward and PICU patients, and preceded the peak CDSS. However, after excluding infants treated with steroids, those hospitalized in the ward had higher VLs than infants requiring PICU care (P < .001). Dynamic analyses showed that VL decay was delayed in PICU patients, especially in those treated with steroids. CONCLUSIONS: Higher VLs at presentation and a faster and consistent VL decline were both associated with less severe RSV disease in children. SUMMARY: Infants with less severe respiratory syncytial virus (RSV) disease had higher viral loads (VL) at presentation, and faster and consistent VL decline. Conversely, VL decay and overall viral exposure were prolonged and higher in infants severe RSV disease receiving steroids.
has issue date	2019-04-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jiy655
bibo:pmid	30418604
has license	no-cc
sha1sum (hex)	a76b38e924387b89e7e80a3aa1df2bd116edbde2
schema:url	https://doi.org/10.1093/infdis/jiy655
resource representing a document's title	Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection
has PubMed Central identifier	PMC6452299
has PubMed identifier	30418604
schema:publication	J Infect Dis
resource representing a document's body	covid:a76b38e924387b89e7e80a3aa1df2bd116edbde2#body_text
is schema:about of	named entity 'loads' named entity 'investigated' named entity 'inpatients' named entity 'loads' named entity 'Infectious Diseases' named entity 'REMAINS' named entity 'CLINICAL' named entity 'DISEASES VIRAL' named entity 'STUDIES' named entity 'RSV INFECTION' named entity 'CLINICAL OUTCOMES' named entity 'SINGLE' named entity 'JOURNAL ' named entity 'DISEASE SEVERITY' named entity 'DISEASE SEVERITY' named entity 'INVESTIGATED' named entity 'INFECTIOUS DISEASES' named entity 'INFANTS' named entity 'RESPIRATORY SYNCYTIAL VIRUS INFECTION' named entity 'VIRAL LOAD' named entity 'DYNAMICS' named entity 'VIRAL' named entity 'DEFINED' named entity 'RELATIONSHIP' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'EVALUATED' named entity 'POINT' named entity 'CHILDREN' named entity 'BACKGROUND' named entity 'OUTPATIENTS' named entity 'HOSPITALIZED CHILDREN' named entity 'ASSOCIATION' named entity 'TIME' named entity 'INPATIENTS' named entity 'VLS' covid:arg/a76b38e924387b89e7e80a3aa1df2bd116edbde2 named entity 'RSV' named entity 'VLs' named entity 'young children' named entity 'RSV' named entity 'nonsteroid' named entity 'urgent care' named entity '0.21' named entity 'PICU' named entity '1.2' named entity 'mechanical ventilation' named entity 'young children' named entity 'mucosal' named entity 'steroids' named entity 'RSV' named entity 'PICU' named entity 'innate immune response' named entity 'PICU' named entity 'interferon' named entity 'therapeutic window' named entity 'RT-PCR' named entity 'PICU' named entity 'respiratory syncytial virus' named entity 'LRTI' named entity 'vaccine' named entity 'steroids' named entity 'steroid' named entity 'sample size' named entity 'morbidity' named entity 'PICU' named entity 'RSV' named entity 'clinical outcomes' named entity 'RSV infection' named entity 'respiratory failure' named entity 'RSV' named entity 'steroids' named entity 'Respiratory syncytial virus' named entity 'primary care clinics' named entity 'LRTI' named entity 'PCR'

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