About: Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor

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About: Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor
Creator	Yu, Ying Ao, Hong Bai, Lijing He, Weiyong Song, Minyan Wang, Chuduan Wang, Xiaoshuo
Source	Elsevier; Medline; PMC
abstract	Abstract During RNA viruses's replication, double-stranded RNA (dsRNA) is normally produced and induce host innate immune response. Most of gene activation due cytokine mediated but which are due to methylation mediated is still unknown. In the study, DNA methylome was integrated with our previous transcriptome data to investigate the differentially methylated regions and genes using MeDIP-chip technology. We found that the transcriptional expressions of 15, 37 and 18 genes were negatively related with their promoter DNA methylation levels in the cells treated by PolyI:C, Aza-CdR, as well as PolyI:C plus Aza-CdR, respectively, compared with the untreated cells. GO analysis revealed hypo-methylated genes (BNIP3L and CDK9) and a hyper-methylated gene (ZC3HAV1) involved in the host response to viral replication. Our results suggest that these novel genes targeted by DNA methylation can be potential markers relevant to virus replication and host innate immune response to set up a medical model of infectious diseases.
has issue date	2019-12-31(xsd:dateTime)
bibo:doi	10.1016/j.ygeno.2018.09.020
bibo:pmid	30315899
has license	els-covid
sha1sum (hex)	a7e523672c9e7d94acf3c1a63ac75a56e8e578f9
schema:url	https://doi.org/10.1016/j.ygeno.2018.09.020
resource representing a document's title	Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor
has PubMed Central identifier	PMC7125705
has PubMed identifier	30315899
schema:publication	Genomics
resource representing a document's body	covid:a7e523672c9e7d94acf3c1a63ac75a56e8e578f9#body_text
is schema:about of	named entity 'DOUBLE STRANDED RNA' named entity 'levels' named entity 'genes' named entity 'integrated' named entity 'technology' named entity 'CDK9' named entity 'host' named entity 'cell' named entity 'MIMICS' named entity 'HOST' named entity '27S' named entity 'MOST OF' named entity 'ABBREVIATIONS' named entity 'POTENTIAL' named entity 'GENE ACTIVATION' named entity 'SET UP' named entity 'INTEGRATED' named entity 'LEVELS' named entity 'PREVIOUS' named entity 'CYTOKINE ' named entity 'RESULTS' named entity 'DNA METHYLOME' named entity 'PORCINE' named entity 'HYPO' named entity 'MEDIATED' named entity 'STUDY' named entity 'METHYLATED' named entity 'METHYLTRANSFERASES' covid:arg/a7e523672c9e7d94acf3c1a63ac75a56e8e578f9 named entity 'DATA' named entity '28P' named entity 'TARGETED' named entity 'EIGHTEEN' named entity 'METHYLATION' named entity 'TECHNOLOGY' named entity 'ACID' named entity 'UNTREATED' named entity 'HOST RESPONSE' named entity 'RELEVANT' named entity 'SYNTHETIC' named entity 'RELATED' named entity 'REGIONS' named entity 'MODEL OF' named entity 'UNKNOWN' named entity 'INNATE IMMUNE RESPONSE' named entity 'GENE' named entity 'REPLICATION' named entity 'PK15' named entity 'VIRUS REPLICATION' named entity 'USING' named entity 'CDR' named entity 'AZA' named entity 'COMPARED' named entity 'OUR' named entity 'FOLLOWED BY' named entity 'DEOXYCYTIDINE' named entity 'CELLS' named entity 'THEIR' named entity 'PROMOTER' named entity 'EXTRACELLULAR' named entity 'INDUCE' named entity 'DOUBLE-STRANDED RNA' named entity 'DSRNA' named entity '5-AZA' named entity 'EXPRESSIONS' named entity '80%' named entity 'EPITHELIAL CELL LINE' named entity 'TREATED WITH' named entity 'LIKE' named entity 'DNA METHYLATION' named entity 'PORCINE' named entity 'GENES' named entity 'INHIBITION' named entity 'REGULATED' named entity 'IDENTIFICATION'

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