About: Putting Synthesis into Biology – A Viral View of Genetic Engineering Through de novo Gene and Genome synthesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Putting Synthesis into Biology – A Viral View of Genetic Engineering Through de novo Gene and Genome synthesis
Creator	Mueller, Steffen Wimmer, Eckard Coleman, J
source	Elsevier; Medline; PMC
abstract	The rapid improvements in DNA synthesis technology hold the potential to revolutionize biosciences in the near future. Traditional genetic engineering methods are template dependent and make extensive but laborious use of site-directed mutagenesis to explore the impact of small variations on an existing sequence “theme”. De novo gene and genome synthesis frees the investigator from the restrictions of the pre-existing template and allows for the rational design of any conceivable new sequence theme. Viruses, being amongst the simplest replicating entities, have been at the forefront of the advancing biosciences since the dawn of molecular biology. Viral genomes, especially those of RNA viruses, are relatively short, often less than 10,000 bases long, making them amenable to whole genome synthesis with the currently available technology. For this reason viruses are once again poised to lead the way in the budding field of synthetic biology – for better or worse.
has issue date	2009-03-01(xsd:dateTime)
bibo:doi	10.1016/j.chembiol.2009.03.002
bibo:pmid	19318214
has license	gold-oa
sha1sum (hex)	a813acc37266e266325697747feea229c2299eec
schema:url	https://doi.org/10.1016/j.chembiol.2009.03.002
resource representing a document's title	Putting Synthesis into Biology – A Viral View of Genetic Engineering Through de novo Gene and Genome synthesis
has PubMed Central identifier	PMC2728443
has PubMed identifier	19318214
schema:publication	Chemistry & Biology
resource representing a document's body	covid:a813acc37266e266325697747feea229c2299eec#body_text
is schema:about of	named entity 'technology' named entity 'rapid' named entity 'impact' named entity 'biology' named entity 'View' named entity 'VIRAL' named entity 'BUT' named entity 'POISED' named entity 'MOLECULAR BIOLOGY' named entity 'THEME' named entity 'POTENTIAL' named entity 'LONG' named entity 'DNA SYNTHESIS' named entity 'SMALL' named entity 'FIELD' named entity 'INVESTIGATOR' named entity 'HAVE' named entity 'CURRENTLY' named entity 'FUTURE' covid:arg/a813acc37266e266325697747feea229c2299eec named entity 'NEW' named entity 'HOLD' named entity 'DAWN' named entity 'DESIGN' named entity 'DEPENDENT' named entity 'WORSE' named entity 'SHORT' named entity 'GENOME' named entity 'AVAILABLE' named entity 'RAPID' named entity 'SYNTHESIS' named entity 'EXTENSIVE' named entity 'LESS THAN' named entity 'VIRUSES' named entity 'BEING' named entity 'PUTTING' named entity 'SYNTHESIS' named entity 'BIOLOGY' named entity 'BETTER' named entity 'FREES' named entity 'GENETIC ENGINEERING' named entity 'VIEW' named entity 'GENOME' named entity 'TRADITIONAL' named entity 'GENETIC ENGINEERING' named entity 'NEAR' named entity 'RNA VIRUSES' named entity 'GENE' named entity 'DE NOVO' named entity 'BUDDING' named entity 'IMPACT' named entity 'BASES' named entity 'SEQUENCE' named entity 'DE NOVO' named entity 'WAY' named entity 'REPLICATING' named entity 'ALLOWS' named entity 'METHODS' named entity 'ADVANCING' named entity 'LEAD' named entity '10%' named entity 'SYNTHETIC BIOLOGY' named entity 'GENE' named entity 'USE OF' named entity 'OF SITE' named entity 'VARIATIONS' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'PRE-EXISTING' named entity 'TEMPLATE' named entity 'VIRAL' named entity 'REASON' named entity 'AMENABLE' named entity 'MAKE' named entity 'GENOMES' named entity 'TECHNOLOGY' named entity 'biosciences' named entity 'Viruses' named entity 'short' named entity 'Viral genomes'

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