About: The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19
Creator	Zhu, Mengyan Li, Lu Li, Jie Wu, Jian Wu, Wei Huang, Wang, Zhihua Wu, Zhong, Wang, Qianghu Wang, Shukui Wang, Ziyu Wu, Lingxiang Xia, Xinyi Cai, Yun Bosco, Bakwatanisa Gan, Zhenhua Li, Kening Li, Wanlin Qiao, Qinghua
source	MedRxiv
abstract	Deciphering the dynamic changes of antibodies against SARS-CoV-2 is essential for understanding the immune response in COVID-19 patients. By comprehensively analyzing the laboratory findings of 1,850 patients, we describe the dynamic changes of the total antibody, spike protein (S)-, receptor-binding domain (RBD)-, and nucleoprotein (N)- specific IgM and IgG levels during SARS-CoV-2 infection and recovery. Our results indicate that the S-, RBD-, and N- specific IgG generation of severe/critical COVID-19 patients is one week later than mild/moderate cases, while the levels of these antibodies are 1.5-fold higher in severe/critical patients during hospitalization (P<0.01). The decrease of these IgG levels indicates the poor outcome of severe/critical patients. The RBD- and S-specific IgG levels are 2-fold higher in virus-free patients (P<0.05). Notably, we found that the patients who got re-infected had a low level of protective antibody on discharge. Therefore, our evidence proves that the dynamic changes of antibodies could provide an important reference for diagnosis, monitoring, and treatment, and shed new light on the precise management of COVID-19.
has issue date	2020-05-21(xsd:dateTime)
bibo:doi	10.1101/2020.05.18.20105155
has license	medrxiv
sha1sum (hex)	a9f756f41019c0e6a6696ab39bcbaaafaa63c425
schema:url	https://doi.org/10.1101/2020.05.18.20105155
resource representing a document's title	The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19
resource representing a document's body	covid:a9f756f41019c0e6a6696ab39bcbaaafaa63c425#body_text
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