About: Establishment of an African green monkey model for COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Establishment of an African green monkey model for COVID-19
Creator	Borisevich, Viktoriya Cross, Robert Fenton, Karla Geisbert, Joan Geisbert, Thomas Agans, Krystle Deer, Daniel Dobias, Natalie Foster, Stephanie Heymann, John Levine, Corri Medina, Liana Prasad, Abhishek Woolsey, Courtney
Source	BioRxiv; Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen candidate vaccines and treatments. Nonhuman primates (NHP) are considered the gold standard model for many infectious pathogens as they usually best reflect the human condition. Here, we show that African green monkeys support a high level of SARS-CoV-2 replication and develop pronounced respiratory disease that may be more substantial than reported for other NHP species including cynomolgus and rhesus macaques. In addition, SARS-CoV-2 was detected in mucosal samples of all animals including feces of several animals as late as 15 days after virus exposure. Importantly, we show that virus replication and respiratory disease can be produced in African green monkeys using a much lower and more natural dose of SARS-CoV-2 than has been employed in other NHP studies.
has issue date	2020-05-17(xsd:dateTime)
bibo:doi	10.1101/2020.05.17.100289
bibo:pmid	32511377
has license	cc-by-nc-nd
sha1sum (hex)	aa20b069d1be9f57876d87ad89cb65f19e60b256
schema:url	https://doi.org/10.1101/2020.05.17.100289
resource representing a document's title	Establishment of an African green monkey model for COVID-19
has PubMed Central identifier	PMC7263506
has PubMed identifier	32511377
schema:publication	bioRxiv
resource representing a document's body	covid:aa20b069d1be9f57876d87ad89cb65f19e60b256#body_text
is schema:about of	named entity 'high level' named entity 'SARS-CoV-2' named entity 'species' named entity 'gold standard' named entity 'STUDY' named entity 'NONHUMAN PRIMATES' named entity 'HUMAN' named entity 'DOSE' named entity 'FECES' named entity 'AFRICAN GREEN MONKEYS' named entity 'PATHOGENESIS' named entity 'MODEL' named entity 'EMPLOYED' named entity 'STUDIES' named entity 'COVID-19' named entity 'CYNOMOLGUS' named entity 'ANIMAL MODELS ' named entity 'HERE' named entity 'LOWER' named entity 'dose' named entity 'late' named entity 'candidate' named entity 'Severe acute respiratory syndrome coronavirus 2' named entity 'COVID' named entity 'Animal models' named entity 'respiratory disease' named entity 'mucosal' named entity 'gold standard' named entity 'Italy' named entity 'blood plasma' named entity 'human disease' named entity 'CC-BY-NC-ND 4.0' named entity 'SARS' named entity 'radiographs' named entity 'humoral response' named entity 'wavelength' named entity 'disease enhancement' named entity 'animal models' named entity 'atelectasis' named entity 'Italy' named entity 'infection' named entity 'COVID-19' named entity 'physiological' named entity 'crystal violet' named entity 'titration' named entity 'animal species' named entity 'genome' named entity 'viral RNA' named entity 'SARS-CoV-2' named entity 'pneumonia' named entity 'gastrointestinal' named entity 'bioRxiv' named entity 'SARS-CoV-2' named entity 'SARS-CoV-1' named entity 'hemorrhage' named entity 'SARS-CoV-2' named entity 'CRP' named entity 'clinical testing' named entity 'inflammatory mediators' named entity 'Qiagen' named entity 'SARS-CoV-2' named entity '60 minutes' named entity 'viral replication' named entity 'cynomolgus macaques' named entity 'virus' named entity 'human disease' named entity 'SARS-CoV-2' named entity 'antigen'

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