About: Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India
Creator	Banerjee, Arup Begum, Feroza Das, Sandeepan Mukherjee, Debica Ray, Upasana Thagriki, Dluya Bengal, West Prem, # Tripathi, Prakash
Source	BioRxiv
abstract	India has recently started sequencing SARS-CoV2 genome from clinical isolates. Currently only few sequences are available from three states in India. Kerala was the first state to deposit complete sequence from two isolates followed by one from Gujarat. On April 27, 2020, the first five sequences from the state of West Bengal (Eastern India) were deposited on ‘a global initiative on sharing avian flu data’ (GISAID) platform. In this paper we have analysed the spike protein sequences from all these five isolates and also compared for their similarities or differences with other sequences reported in India and with isolates of Wuhan origin. We report one unique mutation at position 723 and the other at 1124 in the S2 domain of spike protein of the isolates from West Bengal only and one mutation downstream of the receptor binding domain at position 614 in S1 domain which was common with the sequence from Gujarat (a state of western part of India). Mutation in the S2 domain showed changes in the secondary structure of the spike protein at region of mutation. We also studied molecular dynamics using normal mode analyses and found that this mutation decreases the flexibility of S2 domain. Since both S1 and S2 are important in receptor binding followed by entry in the host cells, such mutations may define the affinity or avidity of receptor binding.
has issue date	2020-05-03(xsd:dateTime)
bibo:doi	10.1101/2020.04.28.066985
has license	biorxiv
sha1sum (hex)	ab5abde11e3abfa4bb0709b235f6b233d31c8fef
schema:url	https://doi.org/10.1101/2020.04.28.066985
resource representing a document's title	Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India
schema:publication	bioRxiv
resource representing a document's body	covid:ab5abde11e3abfa4bb0709b235f6b233d31c8fef#body_text
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