About: Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity

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About: Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity
Creator	Schols, Dominique Andrei, Graciela Snoeck, Robert Grabkowska-Drużyc, Magdalena Piotrowska, Dorota
source	Medline; PMC
abstract	1,3-Dipolar cycloaddition of N-methyl C-(diethoxyphosphoryl) nitrone to N3-substituted 6-bromo-2-vinyl-3H-quinazolin-4-ones gave (3-diethoxyphosphoryl) isoxazolidines substituted at C5 with quinazolinones modified at N3. All isoxazolidine cycloadducts were screened for antiviral activity against a broad spectrum of DNA and RNA viruses. Several isoxazolidines inhibited the replication of both thymidine kinase wild-type and deficient (TK(+) and TK(−)) varicella-zoster virus strains at EC(50) in the 5.4–13.6 μΜ range, as well as human cytomegalovirus (EC(50) = 8.9–12.5 μΜ). Isoxazolidines trans-11b, trans-11c, trans-11e, trans-11f/cis-11f, trans-11g, trans-11h, and trans-11i/cis-11i exhibited moderate cytostatic activity towards the human lymphocyte cell line CEM (IC(50) = 9.6–17 μM).
has issue date	2018-07-28(xsd:dateTime)
bibo:doi	10.3390/molecules23081889
bibo:pmid	30060562
has license	cc-by
sha1sum (hex)	ac0a277a70cf2e3e6e51ddb07ad06eae08cc7fef
schema:url	https://doi.org/10.3390/molecules23081889
resource representing a document's title	Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity
has PubMed Central identifier	PMC6222691
has PubMed identifier	30060562
schema:publication	Molecules
resource representing a document's body	covid:ac0a277a70cf2e3e6e51ddb07ad06eae08cc7fef#body_text
is schema:about of	named entity 'DIPOLAR CYCLOADDITION' named entity 'MODIFIED' named entity 'MODERATE' named entity 'ISOXAZOLIDINE' named entity 'NITRONE' named entity 'GAVE' named entity 'DNA' named entity 'DEFICIENT' named entity 'ACTIVITY' named entity 'INHIBITED' named entity 'N-METHYL' named entity '5.4' named entity '13.6' named entity 'CEM' named entity 'N3-' named entity 'HUMAN CYTOMEGALOVIRUS' named entity 'STRAINS' named entity 'WILD-TYPE' named entity 'QUINAZOLINONES' named entity 'ZOSTER' named entity 'MOLECULES' named entity 'RNA VIRUSES' named entity '11I' named entity 'VINYL' named entity 'HUMAN LYMPHOCYTE' named entity 'CELL LINE' named entity '283' named entity 'CYTOSTATIC' named entity 'SYNTHESIS' named entity 'CYTOMEGALOVIRUS' named entity 'ISOXAZOLIDINE' named entity 'CONJUGATES' named entity 'VIRUS' named entity 'ACTIVITY' named entity 'RANGE' named entity 'THYMIDINE KINASE' named entity 'TRANS' named entity 'ANTIVIRAL ACTIVITY' named entity 'N3-' named entity 'VARICELLA-ZOSTER VIRUS' named entity 'BROAD SPECTRUM' named entity 'REPLICATION' named entity '12.5' named entity 'BROMO' covid:arg/ac0a277a70cf2e3e6e51ddb07ad06eae08cc7fef named entity '5.4' named entity 'wild-type' named entity 'trans' named entity 'trans' named entity 'cell line' named entity 'viruses' named entity 'Zoster' named entity 'Virus' named entity 'diastereoisomeric' named entity 'cell lines' named entity 'toluene' named entity 'antiviral activity' named entity 'leukemia' named entity 'carcinoma' named entity 'potency' named entity 'methanol' named entity 'enzyme' named entity 'HeLa cell' named entity 'isoxazolidine' named entity '1,4-dioxane' named entity 'hydrazide' named entity 'biologically active compounds' named entity 'rimantadine' named entity 'Ganciclovir' named entity 'benzamide' named entity 'agglutinin' named entity 'diastereoselectivities' named entity 'viral infections' named entity 'VZV' named entity 'varicella zoster virus' named entity 'antiviral activity' named entity 'Ganciclovir'

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