About: International travelers and genomics uncover a ‘hidden’ Zika outbreak

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	International travelers and genomics uncover a ‘hidden’ Zika outbreak
Creator	Khan, Kamran Watts, Alexander Palacios, Gustavo Baele, Guy Isern, Sharon Kraemer, Moritz Morrison, Andrea Gardner, Lauren Cannons, Andrew Heberlein-Larson, Lea Andersen, Kristian Bhatia, Deepit Gangavarapu, Karthik Grubaugh, Nathan Hamer, Davidson Ladner, Jason Michael, Scott Tan, Amanda Cone, Marshall Gillis, Leah Hentoff, Aaron Kopp Iv, Edgar Kwal, Jaclyn Landis, Vanessa Lichtenberger, Paola Magnani, Diogo Matteson, Nathaniel Oidtman, Rachel Oliveira, Glenn Perkins, T Ricciardi, Michael Saraf, Sharada Scott, Blake Stanek, Danielle Stryker, Ian Vogels, Chantal Watkins, David White, Stephen
source	BioRxiv; MedRxiv
abstract	The ongoing Zika epidemic in the Americas has challenged public health surveillance, response, and control systems. Even as the epidemic appears to be near its end in the Americas, it is unclear whether substantial Zika virus transmission may still be ongoing. This issue is exacerbated by large discrepancies in local case reporting and significant delays in detecting outbreaks due to surveillance gaps. To uncover locations with lingering outbreaks in the Americas, we investigated travel-associated Zika cases diagnosed in the United States and Europe to identify signatures of transmission dynamics that were not captured by local reporting. We found that a large and unreported Zika outbreak occurred in Cuba during 2017, a year after peak transmission in neighboring countries, with cases still appearing in 2018. By sequencing Zika virus from infected travelers, we show that the 2017 outbreak in Cuba was sparked by long-lived lineages of Zika virus introduced from multiple places in the Americas a year prior. Our data suggest that while aggressive mosquito control in Cuba may initially have been effective at mitigating Zika virus transmission, in the absence of vaccines, herd immunity, or strong international coordination, such control measures may need to be maintained to be effective. Our study highlights how Zika virus may still be ‘silently’ spreading in the Americas and provides a framework for more accurately understanding outbreak dynamics.
has issue date	2018-12-14(xsd:dateTime)
bibo:doi	10.1101/496901
has license	medrxiv
sha1sum (hex)	ac1b4acfb4ae29eb4154efb55de129f114e58fbc
schema:url	https://doi.org/10.1101/496901
resource representing a document's title	International travelers and genomics uncover a ‘hidden’ Zika outbreak
schema:publication	bioRxiv
resource representing a document's body	covid:ac1b4acfb4ae29eb4154efb55de129f114e58fbc#body_text
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