About: UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection

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About: UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection
Creator	Crane, Meredith Gaddi, Pamela Peterson, Karin Salazar-Mather, Thais
Source	PMC
abstract	Antiviral defense in the liver during acute infection with the hepatotropic virus murine cytomegalovirus (MCMV) involves complex cytokine and cellular interactions. However, the mechanism of viral sensing in the liver that promotes these cytokine and cellular responses has remained unclear. Studies here were undertaken to investigate the role of nucleic acid-sensing Toll-like receptors (TLRs) in initiating antiviral immunity in the liver during infection with MCMV. We examined the host response of UNC93B1 mutant mice, which do not signal properly through TLR3, TLR7 and TLR9, to acute MCMV infection to determine whether liver antiviral defense depends on signaling through these molecules. Infection of UNC93B1 mutant mice revealed reduced production of systemic and liver proinflammatory cytokines including IFN-α, IFN-γ, IL-12 and TNF-α when compared to wild-type. UNC93B1 deficiency also contributed to a transient hepatitis later in acute infection, evidenced by augmented liver pathology and elevated systemic alanine aminotransferase levels. Moreover, viral clearance was impaired in UNC93B1 mutant mice, despite intact virus-specific CD8+ T cell responses in the liver. Altogether, these results suggest a combined role for nucleic acid-sensing TLRs in promoting early liver antiviral defense during MCMV infection.
has issue date	2012-06-18(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0039161
bibo:pmid	22723955
has license	cc-by
sha1sum (hex)	acb470a7f8d734e4f257454a90cbb1d933d8bebf
schema:url	https://doi.org/10.1371/journal.pone.0039161
resource representing a document's title	UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection
has PubMed Central identifier	PMC3377622
has PubMed identifier	22723955
schema:publication	PLoS One
resource representing a document's body	covid:acb470a7f8d734e4f257454a90cbb1d933d8bebf#body_text
is schema:about of	named entity 'systemic' named entity 'augmented' named entity 'liver' named entity 'liver' named entity 'Innate' named entity 'acute' named entity 'initiating' named entity 'Acute' named entity 'IMMUNITY' named entity 'IFN' named entity 'MURINE CYTOMEGALOVIRUS' named entity 'TLR3' named entity 'CITATION' named entity 'INFLAMMATION' named entity 'UNC93B1' named entity 'NUCLEIC' named entity 'PRODUCTION' named entity 'INITIATING' named entity 'UNC93B1' named entity 'DEFICIENCY' named entity 'ACUTE INFECTION' named entity 'VIRAL' named entity 'TLRS' named entity 'DO NOT' named entity 'MCMV' named entity 'MICE' named entity 'EXAMINED' named entity 'TNF-A' named entity 'MECHANISM' named entity 'MOLECULES' named entity 'TLR7' named entity 'VIRAL CLEARANCE' named entity 'ANTIVIRAL' named entity 'CYTOMEGALOVIRUS INFECTION' named entity 'RESPONSES' named entity 'SUGGEST' named entity 'HEPATITIS' named entity 'INCLUDING' named entity 'UNCLEAR' named entity 'EARLY' named entity 'VIRUS' named entity 'ACUTE' named entity 'LIVER' named entity 'DEFENSE' named entity 'COMPLEX' named entity 'PROMOTING' named entity 'SIGNALING' named entity 'LIVER' named entity 'IL-12' named entity 'THESE' named entity 'INFLAMMATION' named entity 'MUTANT' named entity 'DETERMINE' named entity 'COMPARED' named entity 'TOLL-LIKE RECEPTORS' named entity 'TLR9' named entity 'PATHOLOGY' named entity 'CRANE' named entity 'SIGNAL' named entity 'REDUCED' named entity 'LATER' named entity 'STUDIES' named entity 'COMBINED' named entity 'ANTIVIRAL' named entity 'CYTOKINE ' named entity 'CELLULAR' named entity 'MURINE CYTOMEGALOVIRUS' named entity 'HERE' named entity 'ACUTE' named entity 'IMPAIRED' named entity 'INFECTION' named entity 'REVEALED' named entity 'INTACT' named entity 'DEFENSE' named entity 'ROLE' named entity 'SPECIFIC' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'CD8'

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