About: Upper and Lower Respiratory Tract Viral Infections and Acute Graft Rejection in Lung Transplant Recipients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Upper and Lower Respiratory Tract Viral Infections and Acute Graft Rejection in Lung Transplant Recipients
Creator	Kaiser, L Thomas, Y Bridevaux, P.-O Tapparel, C Aubert, J.-D Garbino, J Meylan, P Rochat, T Soccal, P
source	Medline; PMC
abstract	Background. Lung transplant recipients are frequently exposed to respiratory viruses and are particularly at risk for severe complications. The aim of this study was to assess the association among the presence of a respiratory virus detected by molecular assays in bronchoalveolar lavage (BAL) fluid, respiratory symptoms, and acute rejection in adult lung transplant recipients. Methods. Upper (nasopharyngeal swab) and lower (BAL) respiratory tract specimens from 77 lung transplant recipients enrolled in a cohort study and undergoing bronchoscopy with BAL and transbronchial biopsies were screened using 17 different polymerase chain reaction—based assays. Results. BAL fluid and biopsy specimens from 343 bronchoscopic procedures performed in 77 patients were analyzed. We also compared paired nasopharyngeal and BAL fluid specimens collected in a subgroup of 283 cases. The overall viral positivity rate was 29.3% in the upper respiratory tract specimens and 17.2% in the BAL samples (P < .001). We observed a significant association between the presence of respiratory symptoms and positive viral detection in the lower respiratory tract (P = .012). Conversely, acute rejection was not associated with the presence of viral infection (odds ratio, 0.41; 95% confidence interval, 0.20–0.88). The recovery of lung function was significantly slower when acute rejection and viral infection were both present. Conclusions. A temporal relationship exists between acute respiratory symptoms and positive viral nucleic acid detection in BAL fluid from lung transplant recipients. We provide evidence suggesting that respiratory viruses are not associated with acute graft rejection during the acute phase of infection.
has issue date	2010-07-15(xsd:dateTime)
bibo:doi	10.1086/653529
bibo:pmid	20524853
has license	no-cc
sha1sum (hex)	ad7d93d13bf1754ce102b9e47ea01e5d5e3e7bf4
schema:url	https://doi.org/10.1086/653529
resource representing a document's title	Upper and Lower Respiratory Tract Viral Infections and Acute Graft Rejection in Lung Transplant Recipients
has PubMed Central identifier	PMC7107821
has PubMed identifier	20524853
schema:publication	Clin Infect Dis
resource representing a document's body	covid:ad7d93d13bf1754ce102b9e47ea01e5d5e3e7bf4#body_text
is schema:about of	named entity 'severe' named entity 'symptoms' named entity 'RESPIRATORY VIRUSES' named entity 'RESPIRATORY VIRUSES' named entity 'ADULT' named entity 'AIM' named entity 'DETECTED' named entity 'BACKGROUND' named entity 'PRESENCE OF' named entity 'RESPIRATORY VIRUS' named entity 'COMPLICATIONS' named entity 'ACUTE REJECTION' named entity 'LUNG TRANSPLANT' named entity 'ASSOCIATION' named entity 'STUDY' named entity 'TRANSPLANT RECIPIENTS' named entity 'ASSESS' named entity 'AT RISK' named entity 'CID' named entity '80%' named entity 'SEVERE' named entity 'EXPOSED TO' named entity 'RESPIRATORY SYMPTOMS' named entity 'BRONCHOALVEOLAR LAVAGE' named entity 'MOLECULAR' named entity 'FLUID' named entity 'FREQUENTLY' named entity 'ACUTE REJECTION' covid:arg/ad7d93d13bf1754ce102b9e47ea01e5d5e3e7bf4 named entity 'viruses' named entity 'Rejection' named entity 'severe complications' named entity 'acute rejection' named entity 'nasopharyngeal' named entity 'calcineurin' named entity 'nucleic acid detection' named entity 'bronchoscopies' named entity 'lymphatic drainage' named entity 'case series' named entity 'viral infection' named entity 'viruses' named entity 'bronchoscopies' named entity 'sore throat' named entity 'pretest' named entity 'viral infection' named entity 'acute rejection' named entity 'microbiological' named entity 'coronaviruses' named entity 'bronchoscopy' named entity 'lung transplant' named entity 'acute rejection' named entity 'acute rejection' named entity 'clinical evaluation' named entity 'acute rejection' named entity 'acute rejection' named entity '95% CI' named entity 'acute rejection' named entity 'respiratory symptoms' named entity 'viral infections' named entity 'acute rejection' named entity 'lower respiratory tract' named entity 'coronaviruses' named entity 'viruses' named entity 'virus' named entity 'virus' named entity 'acute rejection' named entity 'cough' named entity 'virus' named entity 'Statistical analysis' named entity 'immunosuppression' named entity 'transbronchial' named entity 'study population' named entity 'FEV'

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