About: Coupling to the surface of liposomes alters the immunogenicity of hepatitis C virus-derived peptides and confers sterile immunity

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About: Coupling to the surface of liposomes alters the immunogenicity of hepatitis C virus-derived peptides and confers sterile immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coupling to the surface of liposomes alters the immunogenicity of hepatitis C virus-derived peptides and confers sterile immunity
Creator	Taneichi, Maiko Uchida, Tetsuya Akatsuka, Toshitaka Kobayashi, Nobuharu Takagi, Akira
source	Elsevier; Medline; PMC
abstract	Abstract We have previously demonstrated that antigens chemically coupled to the surface of liposomes consisting of unsaturated fatty acids were cross-presented by antigen presenting cells to cytotoxic T lymphocytes (CTLs). Liposomal form of immunodominant CTL epitope peptides derived from lymphocytic choriomeningitis virus exhibited highly efficient antiviral CTL responses in immunized mice. In this study, we coupled 15 highly conserved immunodominant CTL epitope peptides derived from hepatitis C virus (HCV) to the surface of liposomes. We also emulsified the peptides in incomplete Freund’s adjuvant, and compared the immune responses of the two methods of presenting the peptides by cytotoxicity induction and interferon-gamma (IFN-γ) production by CD8+ T cells of the immunized mice. We noticed significant variations of the immunogenicity of each peptide between the two antigen delivery systems. In addition, the immunogenicity profiles of the peptides were also different from those observed in the mice infected with recombinant adenoviruses expressing HCV proteins as previously reported. Induction of anti-viral immunity by liposomal peptides was tested by the challenge experiments using recombinant vaccinia viruses expressing corresponding HCV epitopes. One Db-restricted and three HLA-A*0201-restricted HCV CTL epitope peptides on the surface of liposomes were found to confer complete protection to immunized mice with establishment of long-term memory. Interestingly, their protective efficacy seemed to correlate with the induction of IFN-γ producing cells rather than the cytotoxicity induction suggesting that the immunized mice were protected through non-cytolytic mechanisms. Thus, these liposomal peptides might be useful as HCV vaccines not only for prevention but also for therapeutic use.
has issue date	2013-01-04(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2012.11.028
bibo:pmid	23159619
has license	els-covid
sha1sum (hex)	ae508e0c926147281503c01cd5206ee3e0929d33
schema:url	https://doi.org/10.1016/j.bbrc.2012.11.028
resource representing a document's title	Coupling to the surface of liposomes alters the immunogenicity of hepatitis C virus-derived peptides and confers sterile immunity
has PubMed Central identifier	PMC7124229
has PubMed identifier	23159619
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:ae508e0c926147281503c01cd5206ee3e0929d33#body_text
is schema:about of	named entity 'epitopes' named entity 'highly' named entity 'correlate' named entity 'complete' named entity 'liposomes' named entity 'HEPATITIS C VIRUS' named entity 'IMMUNIZED' named entity 'PRODUCING' named entity 'T LYMPHOCYTES' named entity 'ANTIGENS' named entity 'CYTOTOXICITY' named entity 'HEPATITIS C VIRUS' named entity 'USING' named entity 'CHALLENGE' named entity 'CROSS' named entity 'LIPOSOMAL' named entity 'LONG-TERM MEMORY' named entity 'DEMONSTRATED' named entity 'VIRUSES' named entity 'HIGHLY' named entity 'EFFICIENT' named entity 'PEPTIDES' named entity 'CYTOTOXIC' named entity 'MIGHT BE' named entity 'HLA-A' named entity 'DIFFERENT' named entity 'VARIATIONS' named entity 'OF EACH' named entity 'PREVIOUSLY' named entity 'COMPARED' named entity 'ADDITION' named entity 'PREVENTION' named entity 'DELIVERY SYSTEMS' named entity 'T CELLS' named entity 'EXPERIMENTS' named entity 'TESTED' named entity 'RATHER' named entity 'CHEMICALLY' named entity 'LIPOSOMES' named entity 'METHODS' named entity 'COUPLED' named entity 'SURFACE' named entity 'EPITOPES' named entity 'THEIR' named entity 'RESPONSES' named entity 'ADENOVIRUSES' named entity 'THERAPEUTIC USE' named entity 'CELLS' named entity 'PEPTIDES' named entity 'IMMUNITY' named entity 'SURFACE' named entity 'STERILE' named entity 'INDUCTION' named entity 'INFECTED' named entity 'RESTRICTED' named entity 'MECHANISMS' named entity 'PROTEINS' named entity 'IFN' named entity 'THESE' named entity 'PRESENTED' named entity 'CONSERVED' named entity 'UNSATURATED FATTY ACIDS' named entity 'NON-' named entity 'PROTECTION' named entity 'COMPLETE' named entity 'FOUND' named entity 'ANTIGEN DELIVERY' named entity 'USEFUL' named entity 'EPITOPE' named entity 'FORM' named entity 'HAVE' named entity 'DERIVED' named entity 'OBSERVED' named entity 'ESTABLISHMENT' named entity 'STUDY' named entity '27S' named entity 'ANTIGEN PRESENTING CELLS'

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