About: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves

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About: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves
Creator	Woolums, Amelia Hurley, David Brock, Kenny Palomares, Roberto Parrish, Jacqueline
Source	Elsevier; Medline; PMC
abstract	Abstract Immunosuppression caused by bovine viral diarrhea virus (BVDV) has been associated with lymphocyte depletion, leukopenia and impairment of leukocyte function; however, no work has been done on the relationship between BVDV and regulatory T lymphocytes (Tregs). The objective of this study was to compare the mRNA expression of genes associated with Tregs (CD25, FoxP3, CTLA4, and IDO), after experimental infection of beef calves with low (LV) or high (HV) virulence BVDV. Thirty BVDV-naïve calves were randomly assigned to three groups. Calves were intra-nasally inoculated with LV (n =10, strain SD-1) or HV (n =10, strain 1373) BVDV or BVDV-free cell culture medium (control, n =10). Quantitative RT-PCR was used to determine the expression of target genes in tracheo-bronchial lymph nodes and spleen on day 5 post-infection. The mRNA expression of CD25 was up-regulated in tracheo-bronchial lymph nodes of LV (P <0.05), but not in HV compared to the control group. The expression of FoxP3 and CTLA4 was not increased in tracheo-bronchial lymph nodes of either of the BVDV-inoculated groups. A dramatic up-regulation of IDO mRNA was observed in tracheo-bronchial lymph nodes of LV (P <0.05), but not HV compared to the control calves. In conclusion, experimental infection with BVDV did not provide evidence of Treg activation based on expression of FoxP3 and CTL4. Differential expression of CD25 and IDO mRNA on day 5 post-infection with HV or LV BVDV might reflect temporal differences in transcription occurring during the immune response elicited by these viral strains, or differences in viral infectivity of the host cells.
has issue date	2014-12-31(xsd:dateTime)
bibo:doi	10.1016/j.cimid.2014.10.001
bibo:pmid	25456194
has license	els-covid
sha1sum (hex)	aef7ab6172a15c65ed6f8b745d5df80978a3955b
schema:url	https://doi.org/10.1016/j.cimid.2014.10.001
resource representing a document's title	Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves
has PubMed Central identifier	PMC7112516
has PubMed identifier	25456194
schema:publication	Comparative Immunology, Microbiology and Infectious Diseases
resource representing a document's body	covid:aef7ab6172a15c65ed6f8b745d5df80978a3955b#body_text
is schema:about of	named entity 'ANALYSIS' named entity 'viral' named entity 'Quantitative' named entity 'lymph nodes' named entity 'mRNA' named entity 'high' named entity 'EXPERIMENTAL INFECTION' named entity 'SPLEEN' named entity 'ASSOCIATED WITH' named entity 'IDO' named entity 'VIRULENCE' named entity 'REFLECT' named entity 'DAY 5' named entity 'EITHER' named entity 'TO COMPARE' named entity 'THIRTY' named entity 'STUDY' named entity 'DID' named entity 'ASSOCIATED WITH' named entity 'OBJECTIVE' named entity 'SD-1' named entity 'TRANSCRIPTION' covid:arg/aef7ab6172a15c65ed6f8b745d5df80978a3955b named entity 'CTLA4' named entity 'LOW' named entity 'PROVIDE' named entity 'THESE' named entity 'CELL CULTURE' named entity 'INCREASED' named entity 'FUNCTION' named entity 'DETERMINE' named entity 'CAUSED BY' named entity 'TEMPORAL' named entity 'CALVES' named entity 'HIGH' named entity 'BOVINE VIRAL DIARRHEA VIRUS' named entity 'LEUKOCYTE' named entity 'BOVINE VIRAL DIARRHEA VIRUS' named entity 'POST' named entity 'INFECTION' named entity 'MRNA EXPRESSION' named entity 'GENES' named entity 'FOXP3' named entity 'REGULATORY T LYMPHOCYTES' named entity 'UP-REGULATION' named entity 'LEUKOPENIA' named entity 'FREE CELL' named entity 'STRAINS' named entity 'STRAIN' named entity 'HIGH' named entity 'UP-REGULATED' named entity 'IDO' named entity 'COMPARED' named entity 'IMMUNOSUPPRESSION' named entity 'BEEF' named entity 'VIRULENCE' named entity 'CTLA4' named entity 'OBSERVED' named entity 'ACTIVATION' named entity 'CALVES' named entity 'CD25' named entity 'BRONCHIAL' named entity 'BUT' named entity 'TREG' named entity 'LYMPH NODES' named entity 'GENES' named entity 'MRNA' named entity 'CONTROL GROUP' named entity 'BEEF' named entity 'TARGET' named entity 'IMPAIRMENT' named entity '0.05' named entity 'EXPERIMENTAL INFECTION' named entity 'MRNA EXPRESSION' named entity 'VIRAL' named entity 'BASED' named entity 'LYMPHOCYTE DEPLETION'

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