About: SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

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About: SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
Creator	Turner, Joanne Martinez-Sobrido, Luis Carrion, Ricardo Alvarez, Xavier Chen, Christopher Baum, Alina Brasky, Kathleen Kaushal, Deepak Kyratsous, Christos Lee, Patterson, Jean Schlesinger, Larry Staples, Hilary Torrelles, Jordi Dick, Edward Copin, Richard Roy, Khader, Shabaana Ahmed, Mushtaq Ajithdoss, Dharani Alfson, Alvarez, Cynthia Anderson, Timothy Bartley, Carmen Blakley, Alyssa Callery, Jessica Carrion, Chatterjee, Ayan Clemmons, Elizabeth Cole, Journey Corinna, Dutton, John Escareno, Priscilla Escobedo, Ruby Ferdin, Justin Frost, Patrice Ganatra, Shashank Gazi, Michal Giavedoni, Luis Goez-Gazi, Yenny Gonzalez, Olga Goodroe, Gough, Hall-Ursone, Shannan Hallam, Cory Hodara, Vida Klaffke, Benjamin Kumar Singh, Dhiraj Mannino, Amanda Oyejide, Adelekan Parodi, Laura Platt Ii, N Rosas, Bruce Ross, N Sayers, Ken Scordo, Julia Sharan, Riti Singh, Bindu Thippeshappa, Rajesh Voges, Andra
source	BioRxiv
abstract	There are no known cures or vaccines for COVID-19, the defining pandemic of this era. Animal models are essential to fast track new interventions and nonhuman primate (NHP) models of other infectious diseases have proven extremely valuable. Here we compare SARS-CoV-2 infection in three species of experimentally infected NHPs (rhesus macaques, baboons, and marmosets). During the first 3 days, macaques developed clinical signatures of viral infection and systemic inflammation, coupled with early evidence of viral replication and mild-to-moderate interstitial and alveolar pneumonitis, as well as extra-pulmonary pathologies. Cone-beam CT scans showed evidence of moderate pneumonia, which progressed over 3 days. Longitudinal studies showed that while both young and old macaques developed early signs of COVID-19, both groups recovered within a two-week period. Recovery was characterized by low-levels of viral persistence in the lung, suggesting mechanisms by which individuals with compromised immune systems may be susceptible to prolonged and progressive COVID-19. The lung compartment contained a complex early inflammatory milieu with an influx of innate and adaptive immune cells, particularly interstitial macrophages, neutrophils and plasmacytoid dendritic cells, and a prominent Type I-interferon response. While macaques developed moderate disease, baboons exhibited prolonged shedding of virus and extensive pathology following infection; and marmosets demonstrated a milder form of infection. These results showcase in critical detail, the robust early cellular immune responses to SARS-CoV-2 infection, which are not sterilizing and likely impact development of antibody responses. Thus, various NHP genera recapitulate heterogeneous progression of COVID-19. Rhesus macaques and baboons develop different, quantifiable disease attributes making them immediately available essential models to test new vaccines and therapies.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1101/2020.06.05.136481
has license	biorxiv
sha1sum (hex)	af8020b315060f0888636effcb9584ef63747298
schema:url	https://doi.org/10.1101/2020.06.05.136481
resource representing a document's title	SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
schema:publication	bioRxiv
resource representing a document's body	covid:af8020b315060f0888636effcb9584ef63747298#body_text
is schema:about of	named entity 'primate' named entity 'leads' named entity 'inflammatory' named entity 'infection' named entity 'nonhuman primate' named entity 'cytokine' named entity 'lungs' named entity 'viral persistence' named entity 'infection' named entity 'RNA' named entity 'co-receptors' named entity 'marmoset' named entity 'IL-2' named entity 'RNA' named entity 'Hungary' named entity 'cytokine' named entity 'immunohistochemistry' named entity 'lungs' named entity 'gross examination' named entity 'morphologic' named entity 'mediastinal' named entity 'SARS-CoV-2' named entity 'antigen' named entity 'neutrophils' named entity 'CD14'

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