About: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection
Creator	Zhang, Kai Xu, Yan Pryhuber, Gloria Sun, Xin Misra, Ravi Guo, Minzhe Rogers, Lisa Barr, Justinn Buchanan, Justin Chiou, Joshua Faddah, Dina Gaulton, Kyle Hou, Xiaomeng Huyck, Heidie Kudtarkar, Parul Newsome, Jacklyn Nhlbi, Poirion, Olivier Poole, Cory Preissl, Sebastian Verheyden, Jamie Wang, Allen Whitsett, Jeffery Young, Randee
source	BioRxiv
abstract	Respiratory failure is the leading cause of COVID-19 death and disproportionately impacts adults more than children. Here, we present a large-scale snATAC-seq dataset (90,980 nuclei) of the human lung, generated in parallel with snRNA-seq (46,500 nuclei), from healthy donors of ~30 weeks, ~3 years and ~30 years of age. Focusing on genes implicated in SARS-CoV-2 cell entry, we observed an increase in the proportion of alveolar epithelial cells expressing ACE2 and TMPRSS2 in adult compared to young lungs. Consistent with expression dynamics, 10 chromatin peaks linked to TMPRSS2 exhibited significantly increased activity with age and harbored IRF and STAT binding sites. Furthermore, we identified 14 common sequence variants in age-increasing peaks with predicted regulatory function, including several associated with respiratory traits and TMPRSS2 expression. Our findings reveal a plausible contributor to why children are more resistant to COVID-19 and provide an epigenomic basis for transferring this resistance to older populations.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1101/2020.04.12.037580
has license	biorxiv
sha1sum (hex)	af946075ba62783c8cb0ea6c2ca610243ca1b4c5
schema:url	https://doi.org/10.1101/2020.04.12.037580
resource representing a document's title	Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection
schema:publication	bioRxiv
resource representing a document's body	covid:af946075ba62783c8cb0ea6c2ca610243ca1b4c5#body_text
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