About: The interplay of extracellular matrix and microbiome in urothelial bladder cancer

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About: The interplay of extracellular matrix and microbiome in urothelial bladder cancer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The interplay of extracellular matrix and microbiome in urothelial bladder cancer
Creator	Canducci, Filippo Clementi, Massimo Alfano, Massimo Montorsi, Francesco Nebuloni, Manuela Salonia, Andrea
source	PMC
abstract	Many pathological changes in solid tumours are caused by the accumulation of genetic mutations and epigenetic molecular alterations. In addition, tumour progression is profoundly influenced by the environment surrounding the transformed cells. The interplay between tumour cells and their microenvironment has been recognized as one of the key determinants of cancer development and is being extensively investigated. Data suggest that both the extracellular matrix and the microbiota represent microenvironments that contribute to the onset and progression of tumours. Through the introduction of omics technologies and pyrosequencing analyses, a detailed investigation of these two microenvironments is now possible. In urological research, assessment of their dysregulation has become increasingly important to provide diagnostic, prognostic and predictive biomarkers for urothelial bladder cancer. Understanding the roles of the extracellular matrix and microbiota, two key components of the urothelial mucosa, in the sequelae of pathogenic events that occur in the development and progression of urothelial carcinomas will be important to overcome the shortcomings in current bladder cancer treatment strategies. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrurol.2015.292) contains supplementary material, which is available to authorized users.
has issue date	2015-12-15(xsd:dateTime)
bibo:doi	10.1038/nrurol.2015.292
bibo:pmid	26666363
has license	no-cc
sha1sum (hex)	afd2be8671210854e436fb33b002bf7c65f78c8a
schema:url	https://doi.org/10.1038/nrurol.2015.292
resource representing a document's title	The interplay of extracellular matrix and microbiome in urothelial bladder cancer
has PubMed Central identifier	PMC7097604
has PubMed identifier	26666363
schema:publication	Nat Rev Urol
resource representing a document's body	covid:afd2be8671210854e436fb33b002bf7c65f78c8a#body_text
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