About: Enhanced expression of TGFβ protein in lymphoid organs and lung, but not in serum, of pigs infected with a European field isolate of porcine reproductive and respiratory syndrome virus

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About: Enhanced expression of TGFβ protein in lymphoid organs and lung, but not in serum, of pigs infected with a European field isolate of porcine reproductive and respiratory syndrome virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enhanced expression of TGFβ protein in lymphoid organs and lung, but not in serum, of pigs infected with a European field isolate of porcine reproductive and respiratory syndrome virus
Creator	Carrasco, Librado Barranco, Inmaculada Salguero, Francisco Gó Mez-Laguna, Jaime Pallaré, Francisco Rodríguez-Gó Mez, Irene
Source	Elsevier; Medline; PMC
abstract	Abstract Transforming growth factor β (TGFβ) is an immunomodulatory cytokine which is able to modulate the host immune response eliciting an inefficient response against pathogens. In this sense, the role of this cytokine in porcine reproductive and respiratory syndrome (PRRS) has been poorly studied and the reported results are contradictory. Thus, in the present study, the expression of TGFβ was analysed both at tissue (lymphoid organs and lung) and serum level to study its correlation with the expression of PRRS virus (PRRSV). To carry out this study, 32 pigs were inoculated with the European PRRSV field isolate 2982 and sequentially killed from 0dpi to the end of the study (24dpi). Blood and tissue samples were collected to determine the expression of PRRSV and TGFβ. PRRSV was detected in inoculated animals from 3dpi until the end of the study, however TGFβ was not detected in sera from inoculated animals. Contrary, an increase of TGFβ antigen was observed both in the lymphoid organs and in the lung of PRRSV-inoculated pigs when compared with control group. Since TGFβ play a role as an immunomodulatory cytokine of the immune response and also in the differentiation of regulatory T cells (Tregs), the upregulation of the TGFβ at tissue level may play a role in the impairment of the host immune response observed during PRRS, being observed a significant correlation between PRRSV and TGFβ expression at lung level.
has issue date	2012-07-06(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2012.02.003
bibo:pmid	22397935
has license	els-covid
sha1sum (hex)	b0117852218c4404e51fdefa66d21addc415d039
schema:url	https://doi.org/10.1016/j.vetmic.2012.02.003
resource representing a document's title	Enhanced expression of TGFβ protein in lymphoid organs and lung, but not in serum, of pigs infected with a European field isolate of porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC7125780
has PubMed identifier	22397935
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:b0117852218c4404e51fdefa66d21addc415d039#body_text
is schema:about of	named entity 'respiratory' named entity 'LUNG' named entity 'INFECTED' named entity 'LYMPHOID ORGANS' named entity 'PIGS' named entity 'SERUM' named entity 'EUROPEAN' named entity 'ISOLATE' named entity 'EXPRESSION' named entity 'PROTEIN ' named entity 'FIELD' named entity 'TGFB' named entity 'BUT' named entity 'ENHANCED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'reproductive' named entity 'porcine' named entity 'Enhanced expression' named entity 'protein' named entity 'TGFb' named entity 'lung' named entity 'lymphoid organs' named entity 'porcine reproductive and respiratory syndrome virus' named entity 'serum' named entity 'TGFb' named entity 'lymphoid organs' named entity 'isolate' named entity 'Enhanced expression' named entity 'lung' named entity 'protein' named entity 'virus' named entity 'infected' named entity 'pigs'
is part of of	Enhanced expression of TGFβ protein in lymphoid organs and lung, but not in serum, of pigs infected with a European field isolate of porcine reproductive and respiratory syndrome virus Abstract Transforming growth factor β (TGFβ) is an immunomodulatory cytokine which is able to modulate the host immune response eliciting an inefficient response against pathogens. In this sense, the role of this cytokine in porcine reproductive and respiratory syndrome (PRRS) has been poorly studied and the reported results are contradictory. Thus, in the present study, the expression of TGFβ was analysed both at tissue (lymphoid organs and lung) and serum level to study its correlation with the expression of PRRS virus (PRRSV). To carry out this study, 32 pigs were inoculated with the European PRRSV field isolate 2982 and sequentially killed from 0dpi to the end of the study (24dpi). Blood and tissue samples were collected to determine the expression of PRRSV and TGFβ. PRRSV was detected in inoculated animals from 3dpi until the end of the study, however TGFβ was not detected in sera from inoculated animals. Contrary, an increase of TGFβ antigen was observed both in the lymphoid organs and in the lung of PRRSV-inoculated pigs when compared with control group. Since TGFβ play a role as an immunomodulatory cytokine of the immune response and also in the differentiation of regulatory T cells (Tregs), the upregulation of the TGFβ at tissue level may play a role in the impairment of the host immune response observed during PRRS, being observed a significant correlation between PRRSV and TGFβ expression at lung level. covid:b0117852218c4404e51fdefa66d21addc415d039#body_text

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