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About:
Increased in-hospital mortality from COVID-19 in patients with schizophrenia
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wasabi.inria.fr
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research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Increased in-hospital mortality from COVID-19 in patients with schizophrenia
Creator
Jimeno, Marie-Thérèse
Leone, Marc
Antonini, François
Auquier, Pascal
Boyer, Laurent
Fabre, Cyprien
Fond, Guillaume
François, Msc
Klay, Sophie
Lancon, Christophe
Md, Antonini
Msc, Klay
Orleans, Veronica
Pauly, Vanessa
Sanz, Michel
Sophie, Msc
source
Elsevier; PMC
abstract
Abstract Background: There is limited information describing the presenting characteristics and outcomes of patients with schizophrenia (SCZ) requiring hospitalization for coronavirus disease 2019 (COVID-19). Aims: We aimed to compare the clinical characteristics and outcomes of COVID-19 SCZ patients with those of non-SCZ patients. Method: This was a case-control study of COVID-19 patients admitted to 4 APHM/AMU acute care hospitals in Marseille, southern France. COVID-19 infection was confirmed by a positive result on polymerase chain reaction testing of a nasopharyngeal sample and/or on chest computed scan among patients requiring hospital admission. The primary outcome was in-hospital mortality. The secondary outcome was intensive care unit (ICU) admission. Results: A total of 1092 patients were included. The overall in-hospital mortality rate was 9.0%. The SCZ patients had an increased mortality compared to the non-SCZ patients (26.7% vs. 8.7%, p=0.039), which was confirmed by the multivariable analysis after adjustment for age, sex, smoking status, obesity and comorbidity (adjusted odds ratio 4.36 [95% CI 1.09-17.44]; p=0.038). In contrast, the SCZ patients were not more frequently admitted to the ICU than the non-SCZ patients. Importantly, the SCZ patients were mostly institutionalized (63.6%, 100% of those who died), and they were more likely to have cancers and respiratory comorbidities. Conclusions: This study suggests that SCZ is not overrepresented among COVID-19 hospitalized patients, but SCZ is associated with excess COVID-19 mortality, confirming the existence of health disparities described in other somatic diseases.
has issue date
2020-07-30
(
xsd:dateTime
)
bibo:doi
10.1016/j.encep.2020.07.003
has license
els-covid
sha1sum (hex)
b3654582539ca50a6967bafdd7d8ba2c50960408
schema:url
https://doi.org/10.1016/j.encep.2020.07.003
resource representing a document's title
Increased in-hospital mortality from COVID-19 in patients with schizophrenia
has PubMed Central identifier
PMC7392112
schema:publication
Encephale
resource representing a document's body
covid:b3654582539ca50a6967bafdd7d8ba2c50960408#body_text
is
schema:about
of
named entity 'PAS'
named entity 'liens'
named entity 'SCZ'
named entity 'mechanical ventilation'
named entity 'medical record'
named entity 'hospital care'
named entity 'Respiratory rate'
named entity 'auteurs'
named entity 'SCZ'
named entity 'COVID-19'
named entity 'Normandy'
named entity 'COVID'
named entity 'SCZ'
named entity 'infection'
named entity 'comorbidities'
named entity 'SCZ'
named entity 'ICD10'
named entity 'coronavirus'
named entity 'AMU'
named entity 'health disparities'
named entity 'France'
named entity 'COVID'
named entity 'Charlson comorbidity index'
named entity 'general population'
named entity 'homelessness'
named entity 'SAPS II'
named entity 'hydroxychloroquine'
named entity 'mortality'
named entity 'COVID'
named entity 'COVID'
named entity 'China'
named entity 'French Ministry of Health'
named entity 'COVID'
named entity 'COVID'
named entity 'COVID'
named entity 'COVID-19'
named entity 'general population'
named entity 'acute care'
named entity 'median age'
named entity 'SCZ'
named entity 'SCZ'
named entity 'SCZ'
named entity 'SCZ'
named entity 'social distancing'
named entity 'COVID'
named entity 'general population'
named entity 'co-morbidities'
named entity 'Charlson comorbidity index'
named entity 'Mann-Whitney'
named entity 'general population'
named entity 'SCZ'
named entity 'SCZ'
named entity 'pulmonary embolism'
named entity 'missing data'
named entity 'comorbidities'
named entity 'infection'
named entity 'SCZ'
named entity 'SCZ'
named entity 'ICU'
named entity 'COVID-19'
named entity 'mental disorder'
named entity 'electronic health records'
named entity 'schizophrenia'
named entity 'Corsica'
named entity 'negative symptoms'
named entity 'ICU'
named entity 'China'
named entity 'obesity'
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