About: Antigenic analysis of feline coronaviruses with monoclonal antibodies (MAbs): Preparation of MAbs which discriminate between FIPV strain 79-1146 and FECV strain 79-1683

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About: Antigenic analysis of feline coronaviruses with monoclonal antibodies (MAbs): Preparation of MAbs which discriminate between FIPV strain 79-1146 and FECV strain 79-1683 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antigenic analysis of feline coronaviruses with monoclonal antibodies (MAbs): Preparation of MAbs which discriminate between FIPV strain 79-1146 and FECV strain 79-1683
Creator	Hohdatsu, T Koyama, H Okada, S Sasamoto, T
source	Elsevier; Medline; PMC
abstract	Abstract We prepared 31 monoclonal antibodies (MAbs) against either FIPV strain 79-1146 or FECV strain 79-1683, and tested them for reactivity with various coronaviruses by indirect flourescent antibody assay (IFA). Sixteen MAbs which reacted with all of the 11 strains of feline coronaviruses, also reacted with canine coronavirus (CCV) and transmissible gastroenteritis virus (TGEV). In many of them, the polypeptide specifity was the recognition of transmembrane (E1) protein of the virus. We succeeded in obtaining MAbs which did not react with eight strains FIPV Type I viruses (showing cell-associated growth) but reacted with FIPV Type II (79-1146, KU-1) and/or FECV Type II (79-1683) viruses (showing non-cell associated growth). These MAbs also reacted with CCV or TGEV. These MAbs recognized peplomer (E2) glycoprotein, and many antigenic differences were found in this E2 protein. These results suggest that FIPV Type II and FECV Type II viruses are antigenically closer to TGEV or CCV than to FIPV Type I viruses. Furthermore, the MAb prepared in this study has enabled discrimination between FIPV strain 79-1146 and FECV strain 79-1683, which was thought to be impossible by the previous serological method.
has issue date	1991-06-30(xsd:dateTime)
bibo:doi	10.1016/0378-1135(91)90096-x
bibo:pmid	1653482
has license	els-covid
sha1sum (hex)	b376d7ed7e6f52c801256dcbaf3133b1a11d07e3
schema:url	https://doi.org/10.1016/0378-1135%2891%2990096-x
resource representing a document's title	Antigenic analysis of feline coronaviruses with monoclonal antibodies (MAbs): Preparation of MAbs which discriminate between FIPV strain 79-1146 and FECV strain 79-1683
has PubMed Central identifier	PMC7117509
has PubMed identifier	1653482
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:b376d7ed7e6f52c801256dcbaf3133b1a11d07e3#body_text
is schema:about of	named entity '1991' named entity 'STRAIN' named entity 'H.%' named entity '1146' named entity 'DISCRIMINATE' named entity 'FIPV' named entity 'FIPV' named entity 'MONOCLONAL ANTIBODIES' named entity 'PREPARATION' named entity 'FELINE' named entity 'CORONAVIRUSES' named entity 'PREPARATION' named entity 'CORONAVIRUSES' named entity 'STRAIN' named entity 'VET' named entity 'MONOCLONAL ANTIBODIES' named entity 'ANALYSIS' named entity 'FECV' named entity 'FELINE' named entity 'FECV' named entity 'ANALYSIS' named entity '1146' named entity 'DISCRIMINATE' named entity 'MAbs' named entity 'feline' named entity 'FIPV' named entity 'coronaviruses' named entity 'MAbs' named entity 'ammonium sulfate precipitation' named entity 'FIPV' named entity 'serum' named entity 'CPK' named entity 'Polyethyleneglycol' named entity 'virus' named entity 'MAbs' named entity 'coronaviruses' named entity 'feline infectious peritonitis virus' named entity 'viruses' named entity 'cell culture' named entity 'antigenic' named entity 'KU-2' named entity 'protein' named entity 'MAbs' named entity 'MAbs' named entity '7.2' named entity 'polypeptide' named entity 'coronaviruses' named entity 'thymidine' named entity 'antigenic' named entity 'serologically' named entity 'MEM' named entity 'hybridoma' named entity 'viruses' named entity 'agar gel' named entity 'supernatant' named entity 'antisera' named entity 'FIPV' named entity 'hypoxanthine' named entity 'enteritis' named entity 'MAbs' named entity 'protein' named entity 'fractionation' named entity 'MAbs' named entity '20%' named entity 'FIPV' named entity 'viruses' named entity 'MAbs' named entity 'FIPV' named entity 'serological' named entity 'nitrocellulose' named entity 'antibody' named entity 'serological' named entity 'mice' named entity 'MAbs' named entity 'MAbs' named entity 'microplates' named entity 'fetal calf serum' named entity 'MAbs'

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