About: Imbalance of Th17/Tregs in rats with smoke inhalation-induced acute lung injury

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About: Imbalance of Th17/Tregs in rats with smoke inhalation-induced acute lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Imbalance of Th17/Tregs in rats with smoke inhalation-induced acute lung injury
Creator	Zhang, Fan Wang, Lan, Ya-Ting Li, Mian-Yang
source	PMC
abstract	T helper (Th) 17 cells and CD4(+) CD25(+) regulatory T (Treg) cells are supposed to be critically involved in regulating autoimmune and inflammatory diseases. The aim of this study was to investigate the Th17/Treg pattern in rats with gunpowder smog-induced acute lung injury. Wistar rats were equally randomized to three groups: normal control group, ALI 6 h group (smoke inhalation for 6 h) and ALI 24 h group (smoke inhalation for 24 h). We observed changes in cell counting in bronchoalveolar lavage fluid (BALF), alveolar-capillary membrane permeability and lung tissue pathology. Moreover, rats in ALI 6 h and ALI 24 h group showed increased expression of Th17 cell and related cytokines (IL-17 A, IL-6, TGF-β and IL-23). Meanwhile, Treg prevalence and related cytokines (IL-10, IL-2 and IL-35) were decreased. Consequently, the ratio of Th17/Treg was higher after smoke inhalation. Additionally, Th1 cell decreased while Th2 cell increased at 6 h and 24 h after smoke inhalation. In conclusion, Th17/Treg imbalance exists in rats with smoke inhalation-induced acute lung injury, suggesting its potential role in the pathogenesis of this disease.
has issue date	2016-02-17(xsd:dateTime)
bibo:doi	10.1038/srep21348
bibo:pmid	26884314
has license	cc-by
sha1sum (hex)	b4077f7b80e82291827ff5307171c3a5cb63b3ef
schema:url	https://doi.org/10.1038/srep21348
resource representing a document's title	Imbalance of Th17/Tregs in rats with smoke inhalation-induced acute lung injury
has PubMed Central identifier	PMC4756332
has PubMed identifier	26884314
schema:publication	Sci Rep
resource representing a document's body	covid:b4077f7b80e82291827ff5307171c3a5cb63b3ef#body_text
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