About: Subcellular localization and membrane association of SARS-CoV 3a protein

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About: Subcellular localization and membrane association of SARS-CoV 3a protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Subcellular localization and membrane association of SARS-CoV 3a protein
Creator	Chen, Jiapei Cong, Yuwen Shan, Yajun Yuan, Xiaoling Zhao, Zhenhu Yao, Zhenyu Wang, Shengqi Chen, Bo Dong, Bo Li, Jianyong Yang, Zhen
Source	Elsevier; Medline; PMC
abstract	Abstract SARS-CoV 3a protein was a unique protein of SARS coronavirus (SARS-CoV), which was identified in SARS-CoV infected cells and SARS patients’ specimen. Recent studies revealed that 3a could interact specifically with many SARS-CoV structural proteins, such as M, E and S protein. Expressed 3a protein was reported to localize to Golgi complex in SARS-CoV infected cells. In this study, it was shown that 3a protein was mainly located in Golgi apparatus with different tags at N- or C-terminus. The localization pattern was similar in different transfected cells. With the assay of truncated 3a protein, it was shown that 3a might contain three transmembrane regions, and the second or third region was properly responsible for Golgi localization. By ultra-centrifugation experiment with different extraction buffers, it was confirmed that 3a was an integral membrane protein and embedded in the phospholipid bilayer. Immunofluorescence assay indicated that 3a was co-localized with M protein in Golgi complex in co-transfected cells. These results provide a new insight for further study of the 3a protein on the pathogenesis of SARS-CoV.
has issue date	2005-05-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2005.01.001
bibo:pmid	15763150
has license	els-covid
sha1sum (hex)	b43db9f9a8a30bfeac5cac7ce276153ccec3166d
schema:url	https://doi.org/10.1016/j.virusres.2005.01.001
resource representing a document's title	Subcellular localization and membrane association of SARS-CoV 3a protein
has PubMed Central identifier	PMC7114198
has PubMed identifier	15763150
schema:publication	Virus Research
resource representing a document's body	covid:b43db9f9a8a30bfeac5cac7ce276153ccec3166d#body_text
is schema:about of	named entity 'ASSAY' named entity 'GOLGI LOCALIZATION' named entity 'TAGS' named entity 'RESULTS' named entity 'SARS CORONAVIRUS' named entity 'PROVIDE' named entity 'SECOND' named entity 'STUDIES' named entity 'CELLS' named entity 'BUFFERS' named entity 'IDENTIFIED' named entity 'GOLGI APPARATUS' named entity 'REPORTED' named entity 'STRUCTURAL PROTEINS' covid:arg/b43db9f9a8a30bfeac5cac7ce276153ccec3166d named entity 'SUBCELLULAR LOCALIZATION' named entity 'LOCALIZATION' named entity 'SARS' named entity 'ULTRA-CENTRIFUGATION' named entity 'LOCATED IN' named entity 'CONFIRMED' named entity 'NEW' named entity 'UNIQUE' named entity 'STUDY' named entity 'INTEGRAL MEMBRANE PROTEIN' named entity 'REVEALED' named entity 'EMBEDDED' named entity 'SIMILAR' named entity 'REGION' named entity 'PATHOGENESIS' named entity 'EXTRACTION' named entity 'MEMBRANE' named entity 'C-TERMINUS' named entity 'M PROTEIN' named entity 'PROTEIN' named entity 'SARS-COV' named entity 'GOLGI COMPLEX' named entity 'WAS A' named entity 'PROTEIN' named entity 'TO LOCALIZE' named entity 'PHOSPHOLIPID BILAYER' named entity 'S PROTEIN' named entity 'RESPONSIBLE' named entity 'ASSOCIATION' named entity 'SPECIMEN' named entity 'PATIENTS' named entity 'PATTERN' named entity 'EXPERIMENT' named entity 'INSIGHT' named entity 'THESE' named entity 'INTERACT' named entity 'INDICATED' named entity 'CONTAIN' named entity 'DIFFERENT' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'SARS-COV' named entity 'TRANSMEMBRANE REGIONS' named entity 'INFECTED' named entity 'EXPRESSED' named entity 'LOCALIZED' named entity 'TRUNCATED' named entity 'PROTEIN ' named entity 'RECENT' named entity 'phospholipid bilayer' named entity 'Golgi' named entity 'protein' named entity 'SARS-CoV' named entity 'ultra-centrifugation' named entity 'buffers' named entity 'SARS coronavirus' named entity 'Golgi complex'

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