About: Host receptors: the key to establishing cells with broad viral tropism for vaccine production

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About: Host receptors: the key to establishing cells with broad viral tropism for vaccine production Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host receptors: the key to establishing cells with broad viral tropism for vaccine production
Creator	Abrahamyan, Levon Dai, Xiaofeng Zhang, Xuanhao Ostrikov, Kostya
Source	Medline; PMC
abstract	Cell culture-based vaccine technology is a flexible and convenient approach for vaccine production that requires adaptation of the vaccine strains to the new cells. Driven by the motivation to develop a broadly permissive cell line for infection with a wide range of viruses, we identified a set of the most relevant host receptors involved in viral attachment and entry. This identification was done through a review of different viral entry pathways and host cell lines, and in the context of the Baltimore classification of viruses. In addition, we indicated the potential technical problems and proposed some solutions regarding how to modify the host cell genome in order to meet industrial requirements for mass production of antiviral vaccines. Our work contributes to a finer understanding of the importance of breaking the host–virus recognition specificities for the possibility of creating a cell line feasible for the production of vaccines against a broad spectrum of viruses.
has issue date	2020-03-23(xsd:dateTime)
bibo:doi	10.1080/1040841x.2020.1735992
bibo:pmid	32202955
has license	no-cc
sha1sum (hex)	b63e39a5ddbfc6e1c9a66f2bede0aa960e999f30
schema:url	https://doi.org/10.1080/1040841x.2020.1735992
resource representing a document's title	Host receptors: the key to establishing cells with broad viral tropism for vaccine production
has PubMed Central identifier	PMC7113910
has PubMed identifier	32202955
schema:publication	Crit Rev Microbiol
resource representing a document's body	covid:b63e39a5ddbfc6e1c9a66f2bede0aa960e999f30#body_text
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