About: Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development

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About: Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development
Creator	Alsufyani, Faisal Mattoo, Hamid Pillai, Shiv Rosenberg, Ian Mahajan, Vinay
source	Medline; PMC
abstract	We used Casd1-deficient mice to confirm that this enzyme is responsible for 9-O-acetylation of sialic acids in vivo. We observed a complete loss of 9-O-acetylation of sialic acid on the surface of myeloid, erythroid and CD4(+) T cells in Casd1-deficient mice. Although 9-O-acetylation of sialic acids on multiple hematopoietic lineages was lost, there were no obvious defects in hematopoiesis. Interestingly, erythrocytes from Casd1-deficient mice also lost reactivity to TER-119, a rat monoclonal antibody that is widely used to mark the murine erythroid lineage. The sialic acid glyco-epitope recognized by TER-119 on erythrocytes was sensitive to the sialic acid O-acetyl esterase activity of the hemagglutinin-esterase from bovine coronavirus but not to the corresponding enzyme from the influenza C virus. During erythrocyte development, TER-119(+) Ery-A and Ery-B cells could be stained by catalytically inactive bovine coronavirus hemagglutinin-esterase but not by the inactive influenza C hemagglutinin-esterase, while TER-119(+) Ery-C cells and mature erythrocytes were recognized by both virolectins. Although the structure of the sialoglycoconjugate recognized by TER-119 was not chemically demonstrated, its selective binding to virolectins suggests that it may be comprised of a 7,9-di-O-acetyl form of sialic acid. As erythrocytes mature, the surfaces of Ery-C cells and mature erythrocytes also acquire an additional distinct CASD1-dependent 9-O-acetyl sialic acid moiety that can be recognized by virolectins from both influenza C and bovine coronavirus.
has issue date	2019-01-07(xsd:dateTime)
bibo:doi	10.1093/glycob/cwy110
bibo:pmid	30597004
has license	green-oa
sha1sum (hex)	b721ffae53a4509f1abe6d463af00fa47dbaa2ca
schema:url	https://doi.org/10.1093/glycob/cwy110
resource representing a document's title	Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development
has PubMed Central identifier	PMC6381321
has PubMed identifier	30597004
schema:publication	Glycobiology
resource representing a document's body	covid:b721ffae53a4509f1abe6d463af00fa47dbaa2ca#body_text
is schema:about of	named entity 'O-ACETYLATION' named entity 'mature' named entity 'sensitive' named entity 'vivo' named entity 'recognized' named entity 'virus' named entity 'multiple' named entity 'lost' named entity 'murine' named entity 'MURINE' named entity 'ITS' named entity 'EPITOPE' named entity 'T CELLS' named entity 'O-ACETYL SIALIC ACID' named entity 'SELECTIVE' named entity 'ERYTHROCYTES' named entity 'TER-119' named entity 'ACETYL ESTERASE' named entity 'MICE' named entity 'CD4' named entity 'STAINED' named entity 'ACETYL' named entity 'FORM' named entity 'HEMATOPOIESIS' named entity 'RAT' named entity 'DEPENDENT' named entity 'B CELLS' named entity 'ACQUIRE' named entity 'DEFICIENT' named entity 'BUT' named entity 'MYELOID' named entity 'SIALIC ACID' named entity 'LINEAGE' named entity 'CONFIRM' named entity 'ERYTHROID' named entity 'O-ACETYLATION' named entity 'COMPLETE' named entity 'INFLUENZA C VIRUS' named entity 'CELLS' named entity 'LOST' named entity 'ERYTHROCYTE DEVELOPMENT' named entity 'HEMAGGLUTININ' named entity 'DISTINCT' named entity 'MATURE' named entity 'ADDITIONAL' named entity 'OBSERVED' named entity 'MOIETY' named entity 'SIALIC ACIDS' named entity 'REACTIVITY' named entity 'IN VIVO' named entity 'MURINE' named entity 'HEMATOPOIETIC' named entity 'WAS SENSITIVE' named entity 'LOSS OF' named entity 'USED' named entity 'INACTIVE' named entity 'BOVINE CORONAVIRUS' named entity 'ALTERATIONS' named entity 'ACID' named entity 'ESTERASE ACTIVITY' named entity 'A 7' named entity 'INFLUENZA' named entity 'RESPONSIBLE' named entity 'MONOCLONAL ANTIBODY' named entity 'BINDING' named entity 'ESTERASE' named entity 'CHEMICALLY' named entity 'SURFACE' named entity 'SENSITIVE TO' named entity 'COULD BE' named entity 'MARK' named entity 'ERY' named entity 'STRUCTURE' named entity 'MULTIPLE' named entity 'CASD1' named entity 'ERYTHROCYTE DEVELOPMENT' named entity 'ENZYME'

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