About: Hemagglutinin-specific neutralization of subacute sclerosing panencephalitis viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hemagglutinin-specific neutralization of subacute sclerosing panencephalitis viruses
Creator	Russell, Stephen Muller, Claude Ngel Muñoz-Alía, Miguel
Source	Medline; PMC
abstract	Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal complication of measles caused by particular mutants of measles virus (MeV) that persist in the brain despite high levels of neutralizing antibodies. We addressed the hypothesis that antigenic drift is involved in the pathogenetic mechanism of SSPE by analyzing antigenic alterations in the MeV envelope hemagglutinin protein (MeV-H) found in patients with SSPE in relation to major circulating MeV genotypes. To this aim, we obtained cDNA for the MeV-H gene from tissue taken at brain autopsy from 3 deceased persons with SSPE who had short (3–4 months, SMa79), average (3.5 years, SMa84), and long (18 years, SMa94) disease courses. Recombinant MeVs with a substituted MeV-H gene were generated by a reverse genetic system. Virus neutralization assays with a panel of anti-MeV-H murine monoclonal antibodies (mAbs) or vaccine-immunized mouse anti-MeV-H polyclonal sera were performed to determine the antigenic relatedness. Functional and receptor-binding analysis of the SSPE MeV-H showed activity in a SLAM/nectin-4–dependent manner. Similar to our panel of wild-type viruses, our SSPE viruses showed an altered antigenic profile. Genotypes A, G3, and F (SSPE case SMa79) were the exception, with an intact antigenic structure. Genotypes D7 and F (SSPE SMa79) showed enhanced neutralization by mAbs targeting antigenic site IIa. Genotypes H1 and the recently reported D4.2 were the most antigenically altered genotypes. Epitope mapping of neutralizing mAbs BH015 and BH130 reveal a new antigenic site on MeV-H, which we designated Φ for its intermediate position between previously defined antigenic sites Ia and Ib. We conclude that SSPE-causing viruses show similar antigenic properties to currently circulating MeV genotypes. The absence of a direct correlation between antigenic changes and predisposition of a certain genotype to cause SSPE does not lend support to the proposed antigenic drift as a pathogenetic mechanism in SSPE.
has issue date	2018-02-21(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0192245
bibo:pmid	29466428
has license	cc-by
sha1sum (hex)	b7240857da81a0bee7cfb964a7e838f7f1120b46
schema:url	https://doi.org/10.1371/journal.pone.0192245
resource representing a document's title	Hemagglutinin-specific neutralization of subacute sclerosing panencephalitis viruses
has PubMed Central identifier	PMC5821319
has PubMed identifier	29466428
schema:publication	PLoS One
resource representing a document's body	covid:b7240857da81a0bee7cfb964a7e838f7f1120b46#body_text
is schema:about of	named entity 'pathogenetic' named entity 'generated' named entity 'antigenic drift' named entity 'involved' named entity 'viruses' named entity 'intact' named entity 'long' named entity 'sclerosing' named entity 'antigenic drift' named entity 'sclerosing' named entity 'HEMAGGLUTININ' named entity 'SIMILAR' named entity 'THE BRAIN' named entity 'CIRCULATING' named entity 'GENETIC' named entity 'CHANGES' named entity 'CAUSING' named entity 'VIRUSES' named entity 'EXCEPTION' named entity 'COMPLICATION' named entity 'CORRELATION' named entity 'MECHANISM' named entity 'OUR' named entity 'DEFINED' named entity 'POSITION' named entity 'MUTANTS' named entity 'ALTERED' named entity 'PROPERTIES' named entity 'DESIGNATED' named entity 'POLYCLONAL' named entity 'PROGRESSIVE' named entity 'AVERAGE' named entity 'DIRECT' named entity 'VACCINE' named entity 'PERFORMED' named entity 'SUPPORT' named entity 'CONCLUDE' named entity 'BRAIN AUTOPSY' named entity 'TARGETING' named entity 'GENOTYPE' named entity 'RECEPTOR' named entity 'COURSES' named entity 'MONOCLONAL ANTIBODIES' named entity 'HYPOTHESIS' named entity 'DEPENDENT' named entity 'ENVELOPE' named entity 'PERSONS' named entity 'HEMAGGLUTININ' named entity 'MEV' named entity 'IIA' named entity 'PREVIOUSLY' named entity 'SERA' named entity 'LONG' named entity 'HIGH' named entity 'REVERSE' named entity 'SITE' named entity 'NEW' named entity 'PROFILE' named entity 'RECOMBINANT' named entity 'LETHAL' named entity 'ANALYZING' named entity 'REPORTED' named entity 'MEASLES VIRUS' named entity 'EPITOPE MAPPING' named entity 'SHORT' named entity 'IMMUNIZED' named entity 'REVEAL' named entity 'SYSTEM' named entity 'WILD-TYPE' named entity 'ENHANCED' named entity 'INTACT' named entity 'PATIENTS' named entity 'MURINE' named entity 'AIM' named entity 'VIRUSES' named entity 'SSPE' named entity 'TISSUE' named entity 'BINDING ANALYSIS' named entity 'PANEL'

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