About: Protective Immunity against Respiratory Tract Challenge with Yersinia pestis in Mice Immunized with an Adenovirus-Based Vaccine Vector Expressing V Antigen

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About: Protective Immunity against Respiratory Tract Challenge with Yersinia pestis in Mice Immunized with an Adenovirus-Based Vaccine Vector Expressing V Antigen Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protective Immunity against Respiratory Tract Challenge with Yersinia pestis in Mice Immunized with an Adenovirus-Based Vaccine Vector Expressing V Antigen
Creator	Adenovirus-Based, Y Jid, Pestis Vaccine, •
Source	PMC
abstract	The aerosol form of the bacterium Yersinia pestis causes the pneumonic plague, a rapidly fatal disease. At present, no plague vaccines are available for use in the United States. One candidate for the development of a subunit vaccine is the Y. pestis virulence (V) antigen, a protein that mediates the function of the Yersinia outer protein virulence factors and suppresses inflammatory responses in the host. On the basis of the knowledge that adenovirus (Ad) gene-transfer vectors act as adjuvants in eliciting host immunity against the transgene they carry, we tested the hypothesis that a single administration of a replication-defective Ad gene-transfer vector encoding the Y. pestis V antigen (AdsecV) could stimulate strong protective immune responses without a requirement for repeat administration. AdsecV elicited specific T cell responses and high IgG titers in serum within 2 weeks after a single intramuscular immunization. Importantly, the mice were protected from a lethal intranasal challenge of Y. pestis CO92 from 4 weeks up to 6 months after immunization with a single intramuscular dose of AdsecV. These observations suggest that an Ad gene-transfer vector expressing V antigen is a candidate for development of an effective anti-plague vaccine
has issue date	2006-11-01(xsd:dateTime)
bibo:doi	10.1086/507644
bibo:pmid	17041851
has license	no-cc
sha1sum (hex)	b82a7e289836a97e6d2bc4edd7850bdbfa339160
schema:url	https://doi.org/10.1086/507644
resource representing a document's title	Protective Immunity against Respiratory Tract Challenge with Yersinia pestis in Mice Immunized with an Adenovirus-Based Vaccine Vector Expressing V Antigen
has PubMed Central identifier	PMC7109909
has PubMed identifier	17041851
schema:publication	J Infect Dis
resource representing a document's body	covid:b82a7e289836a97e6d2bc4edd7850bdbfa339160#body_text
is schema:about of	named entity 'VECTOR' named entity 'RESPIRATORY TRACT' named entity 'immunization' named entity 'adenovirus' named entity 'tested' named entity 'immunization' named entity 'pneumonic plague' named entity 'observations' named entity 'host' named entity 'Respiratory' named entity 'SINGLE' named entity 'SUPPRESSES' named entity 'DEFECTIVE' named entity 'VIRULENCE' named entity 'MONTHS' named entity 'PROTEIN ' named entity 'MEDIATES' named entity '2 WEEKS' named entity 'ADENOVIRUS' named entity 'UP TO' named entity 'DOSE' named entity 'PLAGUE VACCINE' named entity 'ENCODING' named entity 'LETHAL' named entity 'OUTER' named entity 'ANTIGEN' named entity 'EFFECTIVE' named entity 'IMMUNIZATION' named entity 'IS A' named entity 'VECTOR' named entity 'IGG' named entity 'GENE' named entity 'BACTERIUM' named entity 'HOST' named entity 'TRANSFER' named entity 'FUNCTION' named entity 'RESPONSES' named entity 'BASED' named entity 'IMMUNIZED' named entity 'MICE' named entity 'STIMULATE' named entity 'DEVELOPMENT' named entity 'CHALLENGE' named entity 'V ANTIGEN' named entity 'PROTECTIVE IMMUNITY' named entity 'SERUM' named entity 'VACCINE' named entity 'YERSINIA PESTIS' named entity 'YERSINIA PESTIS' named entity 'USE' named entity 'RAPIDLY' named entity 'FORM' named entity 'SUGGEST' named entity 'OBSERVATIONS' named entity 'T CELL' named entity 'MICE' named entity 'TESTED' named entity 'A PROTEIN' named entity '4 WEEKS' named entity 'INTRANASAL' named entity 'IMMUNE RESPONSES' named entity 'HOST IMMUNITY' named entity 'KNOWLEDGE' named entity 'SUBUNIT VACCINE' named entity 'INTRAMUSCULAR' named entity 'HYPOTHESIS' named entity 'PRESENT' named entity 'ELICITING' named entity 'TRANSGENE' named entity 'ELICITED' named entity 'CAUSES' named entity 'HIGH' named entity 'AVAILABLE' named entity 'V ANTIGEN' named entity 'PLAGUE VACCINES' named entity 'CARRY' named entity 'ADMINISTRATION' named entity 'UNITED STATES' named entity 'ADJUVANTS'

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