About: Binding Ability Prediction between Spike Protein and Human ACE2 Reveals the Adaptive Strategy of SARS-CoV-2 in Humans

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Binding Ability Prediction between Spike Protein and Human ACE2 Reveals the Adaptive Strategy of SARS-CoV-2 in Humans
Creator	Zhang, Qi Huang, Xueyong Liu, Jianbo Wang, Yaohe Li, Xinxin Zhang, Xiaoju Chen, Chunguang Feng, Shuaisheng Guo, Jiancheng Hua, Linlin Jian, Liguo Liu, Danhua Qin, Yaping Shi, Jianxiang Tang, Wenxue Xu, Hongen Xue, Xia Yang, Zengguang
Source	BioRxiv
abstract	SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel coronavirus causing an outbreak of COVID-19 globally in the past six months. A relatively higher divergence on the spike protein of SASR-CoV-2 enables it to transmit across species efficiently. We particularly believe that the adaptive mutations of the receptor-binding domain (RBD) of spike protein in SARS-CoV-2 might be essential to its high transmissibility among humans. Thus here we collected 2,142 high-quality genome sequences of SARS-CoV-2 from 160 regions in over 50 countries and reconstructed their phylogeny, and also analyzed the interaction between the polymorphisms of spike protein and human ACE2 (hACE2). Phylogenetic analysis of SARS-CoV-2 and coronavirus in other hosts show SARS-CoV-2 is highly possible originated from Bat-CoV (RaTG13) found in horseshoe bat and a recombination event may occur on the spike protein of Pangolin-CoV to imbue it the ability to infect humans. Moreover, compared to the S gene of SARS-CoV-2, it is more conserved in the direct-binding sites of RBD and we noticed that spike protein of SARS-CoV-2 may under a consensus evolution to adapt to human hosts better. 3,860 amino acid mutations in spike protein RBD (T333-C525) of SARS-CoV-2 were simulated and their stability and affinity binding to hACE2 (S19-D615) were calculated. Our analysis indicates SARS-CoV-2 could infect humans from different populations with no preference, and a higher divergence in the spike protein of SARS-CoV-2 at the early stage of this pandemic may be a good indicator that could show the pathway of SARS-CoV-2 transmitting from the natural reservoir to human beings.
has issue date	2020-06-25(xsd:dateTime)
bibo:doi	10.1101/2020.06.25.170704
has license	biorxiv
sha1sum (hex)	b89186defba1ea37d1792aeb017e841f39448c08
schema:url	https://doi.org/10.1101/2020.06.25.170704
resource representing a document's title	Binding Ability Prediction between Spike Protein and Human ACE2 Reveals the Adaptive Strategy of SARS-CoV-2 in Humans
schema:publication	bioRxiv
resource representing a document's body	covid:b89186defba1ea37d1792aeb017e841f39448c08#body_text
is schema:about of	named entity 'collected' named entity 'causing' named entity 'SARS-CoV-2' named entity 'transmissibility' named entity 'SARS-CoV-2' named entity 'infect' named entity 'divergence' named entity 'calculated' named entity 'Strategy' named entity 'Adaptive' named entity 'protein' named entity 'human' named entity 'domain' named entity 'humans' named entity 'SARS-CoV-2' named entity 'gene' named entity 'coronavirus' named entity 'adapt' named entity 'Our' named entity 'conserved' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'higher' named entity 'hosts' named entity 'originated' named entity 'SARS-CoV-2' named entity 'spike' named entity 'protein' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'natural reservoir' named entity 'transmissibility' named entity 'gene' named entity 'coronavirus' named entity 'Bat' named entity 'SARS-CoV-2' named entity 'RBD' named entity 'receptor' named entity 'spike protein' named entity 'SARS-CoV-2' named entity 'Adaptive Strategy' named entity 'transmissibility' named entity 'binding affinity' named entity 'SARS-CoV-2' named entity 'gene' named entity 'RBD' named entity 'transmissibility' named entity 'SARS-CoV' named entity 'coronaviruses' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'spike protein' named entity 'phylogeny' named entity 'zoonotic' named entity 'coronavirus' named entity 'RBD' named entity 'SARS-CoV-2' named entity 'receptor' named entity 'SARS-CoV' named entity 'SARS-CoV-2' named entity 'genome' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'Guangxi' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'infection prevention'

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