About: A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome

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About: A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome
Creator	Chen, Feng Li, Hongru Wang, Ping Li, Ran Wang, Chen Wang, Ying Zhou, Ying Sun, Bing Li, Hongyan Chen, Jie Wang, He Duan, Jun Liang, Lirong Chen, Liangan Yang, Lan Li, Yuping Zhang, Yongxiang Li, Chunmei Zhang, Jin Yang, Tian Sun, Lina Weng, Heng He, Hangyong Chen, Yusheng Hu, Mingdong Tong, Jin Wang, Daoxin Sun, Yongchang Bao, Yong Ding, Yanyan Guo, Shuliang He, Bei Ji, Lixi Jin, Faguang Li, Guofeng Li, Yanming Luo, Qin Song, Liqiang Tan, Hai Wang, Changzheng Wei, Luqing Xu, Xiyuan Yang, Jingping Yang, Xiaohong
Source	PMC
abstract	RATIONALE: Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with “early” stage of mild acute respiratory distress syndrome (ARDS, PaO(2)/FIO(2) between 200 and 300). OBJECTIVES: To evaluate whether early NIV can reduce the need for invasive ventilation in patients with pneumonia-induced early mild ARDS. METHODS: Prospective, multicenter, randomized controlled trial (RCT) of NIV compared with conventional administration of oxygen through a Venturi mask. Primary outcome included the numbers of patients who met the intubation criteria. RESULTS: Two hundred subjects were randomized to NIV (n = 102) or control (n = 98) groups from 21 centers. Baseline characteristics were similar in the two groups. In the NIV group, PaO(2)/FIO(2) became significantly higher than in the control group at 2 h after randomization and remained stable for the first 72 h. NIV did not decrease the proportion of patients requiring intubation than in the control group (11/102 vs. 9/98, 10.8% vs. 9.2%, p = 0.706). The ICU mortality was similar in the two groups (7/102 vs. 7/98, 4.9% vs. 3.1%, p = 0.721). Multivariate analysis showed minute ventilation greater than 11 L/min at 48 h was the independent risk factor for NIV failure (OR, 1.176 [95% CI, 1.005–1.379], p = 0.043). CONCLUSIONS: Treatment with NIV did not reduce the need for intubation among patients with pneumonia-induced early mild ARDS, despite the improved PaO(2)/FIO(2) observed with NIV compared with standard oxygen therapy. High minute ventilation may predict NIV failure. TRIAL REGISTRATION: NCT01581229. Registered 19 April 2012 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13054-019-2575-6) contains supplementary material, which is available to authorized users.
has issue date	2019-09-04(xsd:dateTime)
bibo:doi	10.1186/s13054-019-2575-6
bibo:pmid	31484582
has license	cc-by
sha1sum (hex)	b8ae170265930bcb585711d8122f598419c214b0
schema:url	https://doi.org/10.1186/s13054-019-2575-6
resource representing a document's title	A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome
has PubMed Central identifier	PMC6727327
has PubMed identifier	31484582
schema:publication	Crit Care
resource representing a document's body	covid:b8ae170265930bcb585711d8122f598419c214b0#body_text
is schema:about of	named entity 'noninvasive ventilation' named entity '200' named entity 'OXYGEN' named entity 'INTUBATION' named entity 'NONINVASIVE VENTILATION' named entity 'MILD ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'pilot study' named entity 'patients' named entity 'Rationale' named entity 'intubation' named entity 'acute respiratory distress syndrome' named entity 'intubation' named entity 'pneumonia' named entity 'ICU' named entity 'respiratory rate' named entity 'China' named entity 'ARDS' named entity 'NIV' named entity 'pneumonia' named entity 'respiratory rate' named entity 'intubation' named entity 'etiology' named entity 'positive effect' named entity 'log-rank test' named entity 'hospital stays' named entity 'clinical trial' named entity 'Medical Technology' named entity 'Chlamydia' named entity 'ideal body weight' named entity 'intubation' named entity 'body weight' named entity 'NIV' named entity 'NIV' named entity 'control groups' named entity 'diffuse alveolar damage' named entity 'ARDS' named entity 'NIV' named entity 'immune suppression'

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