About: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs
Creator	Berry, Jody Cassan, Robyn Hashiguchi, Takao Li, Sheng Nykiforuk, Cory Shulenin, Sergey Vu, Hong Zeitlin, Larry Fusco, Marnie Olinger, Gene Aman, M Biggins, Julia Holtsberg, Frederick Kim, Do Murin, Charles Saphire, Erica Ward, Andrew Warfield, Kelly Whaley, Kevin
source	PMC
abstract	The filoviruses, which include the marburg- and ebolaviruses, have caused multiple outbreaks among humans this decade. Antibodies against the filovirus surface glycoprotein (GP) have been shown to provide life-saving therapy in nonhuman primates, but such antibodies are generally virus-specific. Many monoclonal antibodies (mAbs) have been described against Ebola virus. In contrast, relatively few have been described against Marburg virus. Here we present ten mAbs elicited by immunization of mice using recombinant mucin-deleted GPs from different Marburg virus (MARV) strains. Surprisingly, two of the mAbs raised against MARV GP also cross-react with the mucin-deleted GP cores of all tested ebolaviruses (Ebola, Sudan, Bundibugyo, Reston), but these epitopes are masked differently by the mucin-like domains themselves. The most efficacious mAbs in this panel were found to recognize a novel “wing” feature on the GP2 subunit that is unique to Marburg and does not exist in Ebola. Two of these anti-wing antibodies confer 90 and 100% protection, respectively, one hour post-exposure in mice challenged with MARV.
has issue date	2015-06-26(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1005016
bibo:pmid	26115029
has license	cc0
sha1sum (hex)	b8efd7ebd2057d44c6544e918c3631ac395c7fb2
schema:url	https://doi.org/10.1371/journal.ppat.1005016
resource representing a document's title	Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs
has PubMed Central identifier	PMC4482612
has PubMed identifier	26115029
schema:publication	PLoS Pathog
resource representing a document's body	covid:b8efd7ebd2057d44c6544e918c3631ac395c7fb2#body_text
is schema:about of	named entity 'primates' named entity 'cross-react' named entity 'provide' named entity 'monoclonal antibodies' named entity 'generally' named entity 'mAbs' named entity 'SURFACE GLYCOPROTEIN' named entity 'CONTRAST' named entity 'EXIST' named entity 'LIFE' named entity 'SPECIFIC' named entity 'GPS' named entity 'ELICITED BY' named entity 'ANTIBODIES' named entity 'PROTECTION' named entity 'DESCRIBED' named entity 'MICE' named entity 'TESTED' named entity 'DECADE' named entity 'POST' named entity 'VIRUS' named entity 'DIFFERENT' named entity 'IMMUNIZATION' named entity 'RECOMBINANT' named entity 'RAISED' named entity 'HERE' named entity 'DOES NOT' named entity 'EXPOSURE' named entity 'TO PROVIDE' named entity 'USING' named entity 'CORES' named entity 'CAUSED' named entity 'NONHUMAN PRIMATES' named entity 'THESE' named entity 'MARBURG VIRUS' named entity 'EBOLA' named entity 'THERAPY' named entity 'GPS' named entity 'EBOLA VIRUS' named entity 'MONOCLONAL ANTIBODIES' named entity 'HAVE' named entity 'STRAINS' named entity 'WING' named entity 'FILOVIRUS' named entity 'ENGINEERED' named entity 'MARBURG VIRUS ' named entity 'RAISED' named entity 'FILOVIRUSES' named entity 'ONE HOUR' named entity 'MULTIPLE' named entity 'RECOGNIZE' named entity 'OUTBREAKS' named entity 'REACT' named entity 'PRESENT' named entity 'NOVEL' named entity 'DELETED' named entity 'SUBUNIT' named entity 'MARBURG VIRUS ' named entity 'CROSS' named entity 'UNIQUE' named entity 'CROSS-REACTIVE' named entity 'LIKE' named entity 'FEATURE'

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