About: DNA vaccines: prime time is now

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	DNA vaccines: prime time is now
Creator	Weiner, David Gary, Ebony
Source	Elsevier; Medline; PMC
abstract	Recently newer synthetic DNA vaccines have been rapidly advanced to clinical study and have demonstrated an impressive degree of immune potency and tolerability. Improvements in DNA delivery over prior needle and syringe approaches include jet delivery, gene gun delivery, among others. Among the most effective of these new delivery methods, advanced electroporation (EP), combined with other advances, induces robust humoral and cellular immunity in both preventative as well as therapeutic studies. Advancements in the design of the DNA inserts include leader sequence changes, RNA and codon optimizations, improved insert designs, increased concentrations of DNA, and skin delivery, appear to complement newer delivery strategies. These advances also provide a framework for the in vivo production of synthetic DNA biologics. In this review, we focus on recent studies of synthetic DNA vaccines in the clinic for the prevention or treatment of infectious diseases with a focus on adaptive electroporation for delivery, and briefly summarize novel preclinical data advancing the in vivo delivery of DNA-encoded antibody-like biologics.
has issue date	2020-04-04(xsd:dateTime)
bibo:doi	10.1016/j.coi.2020.01.006
bibo:pmid	32259744
has license	no-cc
sha1sum (hex)	b97d903ddf28f5d5027b174d4d065acdedbc6457
schema:url	https://doi.org/10.1016/j.coi.2020.01.006
resource representing a document's title	DNA vaccines: prime time is now
has PubMed Central identifier	PMC7195337
has PubMed identifier	32259744
schema:publication	Curr Opin Immunol
resource representing a document's body	covid:b97d903ddf28f5d5027b174d4d065acdedbc6457#body_text
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